Treatment with Mountain-Cultivated Ginseng Alleviates Trimethyltin-Induced Cognitive Impairments in Mice via IL-6-Dependent JAK2/STAT3/ERK Signaling
DC Field | Value | Language |
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dc.contributor.author | Thu-Hien Thi Tu | - |
dc.contributor.author | Sharma, Naveen | - |
dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Hai-Quyen Tran | - |
dc.contributor.author | Lee, Yu Jeung | - |
dc.contributor.author | Nah, Seung-Yeol | - |
dc.contributor.author | Hoang-Yen Phi Tran | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Jeong, Jung Hwan | - |
dc.contributor.author | Ko, Sung Kwon | - |
dc.contributor.author | Byun, Jae Kyung | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.date.available | 2019-03-08T07:38:01Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.issn | 1439-0221 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3712 | - |
dc.description.abstract | Panax ginseng is the most widely used herbal medicine for improving cognitive functions. The pharmacological activity and underlying mechanisms of mountain-cultivated ginseng, however, have yet to be clearly elucidated, in particular, against trimethyltin-induced cognitive dysfunction. We previously reported that interleukin-6 plays a protective role against trimethyltin-induced cognitive dysfunction. Because of this, we have implemented a study system that uses interleukin-6 null (-/-) and wild-type mice. Interestingly, mountain-cultivated ginseng significantly upregulated interleukin-6 expression. With this study, we sought to determine whether the interleukin-6-dependent modulation of the Janus kinase 2/signal transducer activator of transcription 3 and extracellular signal-regulated kinase signaling network is also associated with the pharmacological activity of mountain-cultivated ginseng against trimethyltin-induced cognitive dysfunction. Trimethyltin treatment (2.4 mg/kg, intraperitoneal) causes the downregulation of Janus kinase 2/signal transducer activator of transcription 3, extracellular signal-regulated kinase signaling, and impairment of the cholinergic system. We found that mountain-cultivated ginseng treatment (50 mg/kg, intraperitoneal) significantly attenuated cognitive impairment normally induced by trimethyltin by upregulating p-Janus kinase 2/signal transducer activator of transcription 3, p-extracellular signal-regulated kinase signaling, and the cholinergic system. Trimethyltin-induced cognitive impairments were more pronounced in interleukin-6 (-/-) mice than wild-type mice, and they were markedly reduced by treatment with either mountain-cultivated ginseng or recombinant interleukin-6 protein (6 ng, intracerebroventricular). Additionally, treatment with either AG490 (20 mg/kg, intraperitoneal), a Janus kinase 2/signal transducer activator of transcription 3 inhibitor, or U0126 (2 mu g/head, intracerebroventricular), an extracellular signal-regulated kinase inhibitor, reversed the effects of mountain-cultivated ginseng treatment. The effects of mountain-cultivated ginseng treatment were comparable to those of recombinant interleukin-6 protein in interleukin-6 (-/-) mice. Our results, therefore, suggest that mountain-cultivated ginseng acts through interleukin-6-dependent activation of Janus kinase 2/signal transducer activator of transcription 3/extracellular signal-regulated kinase signaling in order to reverse cognitive impairment caused by trimethyltin treatment. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.title | Treatment with Mountain-Cultivated Ginseng Alleviates Trimethyltin-Induced Cognitive Impairments in Mice via IL-6-Dependent JAK2/STAT3/ERK Signaling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1055/s-0043-111896 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.83, no.17, pp 1342 - 1350 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000415715200005 | - |
dc.identifier.scopusid | 2-s2.0-85020214016 | - |
dc.citation.endPage | 1350 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 1342 | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 83 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | cognitive dysfunction | - |
dc.subject.keywordAuthor | IL-6 knockout mice | - |
dc.subject.keywordAuthor | JAK2/STAT3/ERK signaling | - |
dc.subject.keywordAuthor | cholinergic system | - |
dc.subject.keywordAuthor | Panax ginseng | - |
dc.subject.keywordAuthor | Araliaceae | - |
dc.subject.keywordAuthor | trimethyltin | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
dc.subject.keywordPlus | ORBITOFRONTAL CORTEX | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | RECOGNITION MEMORY | - |
dc.subject.keywordPlus | NEONATAL EXPOSURE | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | PREWEANLING RATS | - |
dc.subject.keywordPlus | M1 MACHR | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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