Autocrine DUSP28 signaling mediates pancreatic cancer malignancy via regulation of PDGF-A
DC Field | Value | Language |
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dc.contributor.author | Lee, Jungwhoi | - |
dc.contributor.author | Lee, Jungsul | - |
dc.contributor.author | Yun, Jeong Hun | - |
dc.contributor.author | Choi, Chulhee | - |
dc.contributor.author | Cho, Sayeon | - |
dc.contributor.author | Kim, Seung Jun | - |
dc.contributor.author | Kim, Jae Hoon | - |
dc.date.available | 2019-03-08T07:55:50Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3788 | - |
dc.description.abstract | Pancreatic cancer remains one of the most deadly cancers with a grave prognosis. Despite continuous efforts to improve remedial values, limited progress has been made. We have reported that dual specificity phosphatase 28 (DUSP28) has a critical role of chemo-resistance and migration in pancreatic cancers. However, its mechanism remains unclear. Here, we further clarify the function of DUSP28 in pancreatic cancers. Analysis using a public microarray database and in vitro assay indicated a critical role of platelet derived growth factor A (PDGF-A) in pancreatic cancer malignancy. PDGF-A was positively regulated by DUSP28 expression at the mRNA and protein levels. Enhanced DUSP28 sensitized pancreatic cancer cells to exogenous PDGF-A treatment in migration, invasion, and proliferation. Transfection with siRNA targeting DUSP28 blunted the influence of administered PDGF-A by inhibition of phosphorylation of FAK, ERK1/2, and p38 signalling pathways. In addition, DUSP28 and PDGF-A formed an acquired autonomous autocrine-signaling pathway. Furthermore, targeting DUSP28 inhibited the tumor growth and migratory features through the blockade of PDGF-A expression and intracellular signaling in vivo. Our results establish novel insight into DUSP28 and PDGF-A related autonomous signaling pathway in pancreatic cancer. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Autocrine DUSP28 signaling mediates pancreatic cancer malignancy via regulation of PDGF-A | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-017-13023-w | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000412492000004 | - |
dc.identifier.scopusid | 2-s2.0-85030756758 | - |
dc.citation.number | 1 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | DUAL-SPECIFICITY PHOSPHATASES | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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