Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendagesopen access
- Authors
- Tsiamantas, Christos; Kwon, Sunbum; Rogers, Joseph M.; Douat, Celine; Huc, Ivan; Suga, Hiroaki
- Issue Date
- Mar-2020
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- foldamers; flexizyme; in vitro translation; peptides; peptidomimetics
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.59, no.12, pp 4860 - 4864
- Pages
- 5
- Journal Title
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Volume
- 59
- Number
- 12
- Start Page
- 4860
- End Page
- 4864
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38032
- DOI
- 10.1002/anie.201914654
- ISSN
- 1433-7851
1521-3773
- Abstract
- Derivatives of 4-aminomethyl-l-phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C-terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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