Intra-articular Injection of Culture-Expanded Mesenchymal Stem Cells Without Adjuvant Surgery in Knee Osteoarthritis: A Systematic Review and Meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seong Hwan | - |
dc.contributor.author | Djaja, Yoshi Pratama | - |
dc.contributor.author | Park, Yong-Beom | - |
dc.contributor.author | Park, Jung-Gwan | - |
dc.contributor.author | Ko, Young-Bong | - |
dc.contributor.author | Ha, Chul-Won | - |
dc.date.available | 2020-04-09T07:20:31Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 0363-5465 | - |
dc.identifier.issn | 1552-3365 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38112 | - |
dc.description.abstract | Background: Although many clinical studies have assessed the efficacy of mesenchymal stem cells (MSCs) in knee osteoarthritis, evidence on their efficacy remains unclear owing to heterogeneity of cell entity and concomitant procedures. Purpose: To determine the efficacy of culture-expanded MSCs in knee osteoarthritis in terms of clinical outcome and cartilage repair via meta-analysis of randomized controlled trials (RCTs) without adjuvant surgery. Study Design: Meta-analysis. Methods: PubMed, Embase, the Cochrane Library, CINAHL, and Scopus were searched from inception to December 31, 2018. RCTs with culture-expanded MSCs for treating knee osteoarthritis were included. Studies with adjuvant surgery or cell concentrate were excluded. Quality was assessed by the Cochrane Collaboration risk-of-bias tool. For meta-analysis, data on clinical outcomes were measured using a visual analog scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and data on cartilage repair were measured using the Whole-Organ Magnetic Resonance Imaging Score (WORMS); categorization related to improvement was extracted. Results: Six RCTs (203 patients) were included. Two studies were deemed to have a low risk of bias. In pooled analysis, the only significant difference was in the VAS score (mean difference, -13.55; 95% CI, -22.19 to -4.9). In cumulative pain analysis with VAS and WOMAC pain scores, there was significant improvement after treatment (standardized mean difference, -0.54; 95% CI, -0.85 to -0.23). There was no significant difference in cartilage repair assessed by magnetic resonance imaging (standardized mean difference, 0.11; 95% CI, -0.51 to 0.73), WORMS (standardized mean difference, 1.68; 95% CI -14.84 to 18.21), or categorical results (odds ratio, 1.56; 95% CI, 0.32-7.59). Conclusion: Intra-articular injection of culture-expanded MSCs without adjuvant surgery can improve pain for patients experiencing knee osteoarthritis at short-term follow-up (6-12 months). However, evidence regarding function and cartilage repair remains limited. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | Intra-articular Injection of Culture-Expanded Mesenchymal Stem Cells Without Adjuvant Surgery in Knee Osteoarthritis: A Systematic Review and Meta-analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/0363546519892278 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF SPORTS MEDICINE, v.48, no.11, pp 2839 - 2849 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000506754900001 | - |
dc.identifier.scopusid | 2-s2.0-85077391409 | - |
dc.citation.endPage | 2849 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2839 | - |
dc.citation.title | AMERICAN JOURNAL OF SPORTS MEDICINE | - |
dc.citation.volume | 48 | - |
dc.type.docType | Review | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | knee | - |
dc.subject.keywordAuthor | osteoarthritis | - |
dc.subject.keywordAuthor | culture expansion | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordPlus | HIGH TIBIAL OSTEOTOMY | - |
dc.subject.keywordPlus | PLATELET-RICH PLASMA | - |
dc.subject.keywordPlus | EVIDENCE-BASED MEDICINE | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | CARTILAGE REGENERATION | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MICROFRACTURE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.relation.journalResearchArea | Orthopedics | - |
dc.relation.journalResearchArea | Sport Sciences | - |
dc.relation.journalWebOfScienceCategory | Orthopedics | - |
dc.relation.journalWebOfScienceCategory | Sport Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.