국가 바이오모니터링 프로그램을 위한 소변 중 금속류 동시분석법 개발 및 검증
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조용민 | - |
dc.contributor.author | 양민호 | - |
dc.contributor.author | 임호섭 | - |
dc.contributor.author | 차상원 | - |
dc.contributor.author | 이재익 | - |
dc.contributor.author | 김기훈 | - |
dc.contributor.author | 한상범 | - |
dc.date.available | 2020-04-14T03:21:19Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1738-4087 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38427 | - |
dc.description.abstract | Objectives: This study developed and validated an analysis method of urinary metals and metalloids that can be applied inductively with coupled plasma mass spectrometry (ICP-MS). Methods: 0.3 mL of urine was used to analyze 25 metal and metalloid compounds using ICP-MS. The validation of the analytical method included linearity, accuracy, precision, and the calculation of detection limits. In addition, a comparison test was performed with the graphite furnace atomic absorption spectrometry (GF-AAS) method, which is the current standard method, with urine samples of 66 healthy subjects. Results: The linearities (R2 ) of calibration curves of all 25 compounds were ≥ 0.999. Of the 25 compounds, the intra-day and inter-day accuracy% of 17 and 20 met ≤15%, respectively. In addition, fifteen compounds showed ≤15% recovery% for certificated reference materials. Intraclass correlation coefficients of the comparison between the current methods and new methods in this study were 0.952 (p-value<0.001) and 0.911 (p-value<0.001) for urinary cadmium and mercury, respectively. Conclusion: This study proposes an efficient simultaneous methodology that can analyze multi elements in smaller sample amounts. More reproduction experiments are needed in the future. | - |
dc.format.extent | 11 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 한국환경보건학회 | - |
dc.title | 국가 바이오모니터링 프로그램을 위한 소변 중 금속류 동시분석법 개발 및 검증 | - |
dc.title.alternative | Development and Validation of the Simultaneous Analytical Method of Urinary Metals and Metalloids for the National Biomonitoring Programs | - |
dc.type | Article | - |
dc.identifier.doi | 10.5668/JEHS.2019.45.6.594 | - |
dc.identifier.bibliographicCitation | 한국환경보건학회지, v.45, no.6, pp 594 - 604 | - |
dc.identifier.kciid | ART002533478 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 604 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 594 | - |
dc.citation.title | 한국환경보건학회지 | - |
dc.citation.volume | 45 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Urinary metals | - |
dc.subject.keywordAuthor | ICP-MS | - |
dc.subject.keywordAuthor | simultaneous analysis | - |
dc.subject.keywordAuthor | biomonitoring | - |
dc.description.journalRegisteredClass | kci | - |
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