Anti-amyloidogenic effects of Perilla frutescens var. acuta on beta-amyloid aggregation and disaggregation
DC Field | Value | Language |
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dc.contributor.author | Kim, Da-Jeong | - |
dc.contributor.author | Kim, Min-Suk | - |
dc.contributor.author | Kim, Sunggun | - |
dc.contributor.author | Hwang, Kwang-Woo | - |
dc.contributor.author | Park, So-Young | - |
dc.date.available | 2019-03-08T07:56:28Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0145-8884 | - |
dc.identifier.issn | 1745-4514 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3847 | - |
dc.description.abstract | Beta-amyloid (A beta) aggregates are a major cause of Alzheimer's disease (AD), and the inhibition of A beta aggregation is a good therapeutic target against AD. Thus, the effects of Perilla extract (4-100 mu g/mL) on the aggregation of A beta (20 mu M) monomers and disaggregation of pre-aggregated A beta aggregates were determined. The Perilla methanol extract and its hexane fraction significantly reduced A beta aggregation determined by a Theoflavin T fluorescence assay (IC50=24.5 and 19.8 mu g/mL, respectively) and confirmed by Western blot analysis with native gels. The inhibition of A beta aggregation by hexane fraction of Perilla extract (20 and 100 mu g/mL) rescued the PC12 cells from A aggregate-induced toxicity to the levels of DMSO-treated control groups. Furthermore, hexane fraction efficiently disaggregated the preformed A beta aggregates (IC50=10.2 mu g/mL). Perilla frutescens var. acuta leaves exhibited anti-amyloidogenic effects against A beta aggregation and disaggregation. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Anti-amyloidogenic effects of Perilla frutescens var. acuta on beta-amyloid aggregation and disaggregation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/jfbc.12393 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FOOD BIOCHEMISTRY, v.41, no.5 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000412117000007 | - |
dc.identifier.scopusid | 2-s2.0-85021745452 | - |
dc.citation.number | 5 | - |
dc.citation.title | JOURNAL OF FOOD BIOCHEMISTRY | - |
dc.citation.volume | 41 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | aggregation | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | beta-amyloid | - |
dc.subject.keywordAuthor | disaggregation | - |
dc.subject.keywordAuthor | Perilla frutescens var | - |
dc.subject.keywordAuthor | acuta | - |
dc.subject.keywordAuthor | polyphenols | - |
dc.subject.keywordPlus | FIBRILS IN-VITRO | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | OIL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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