Survival outcomes of breast cancer patients with brain metastases: A multicenter retrospective study in Korea (KROG 16–12)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jae Sik | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Jung, Wonguen | - |
dc.contributor.author | Shin, Kyung Hwan | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Hee-Jun | - |
dc.contributor.author | Kim, Yong Bae | - |
dc.contributor.author | Chang, Jee Suk | - |
dc.contributor.author | Choi, Doo Ho | - |
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Kim, Dae Yong | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Choi, Byung Ock | - |
dc.contributor.author | Lee, Sea-Won | - |
dc.contributor.author | Kim, Suzy | - |
dc.contributor.author | Kwon, Jeanny | - |
dc.contributor.author | Kang, Ki Mun | - |
dc.contributor.author | Chung, Woong-Ki | - |
dc.contributor.author | Kim, Kyung Su | - |
dc.contributor.author | Nam, Ji Ho | - |
dc.contributor.author | Yoon, Won Sup | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Cha, Jihye | - |
dc.contributor.author | Oh, Yoon Kyeong | - |
dc.contributor.author | Kim, In Ah | - |
dc.date.available | 2020-04-16T07:20:07Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 0960-9776 | - |
dc.identifier.issn | 1532-3080 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38494 | - |
dc.description.abstract | Purpose: This study evaluated the influence of prognostic factors and whole brain radiotherapy (WBRT) on overall survival (OS) of breast cancer (BC) patients with brain metastases (BM). Methods and materials: Medical records of 730 BC patients diagnosed with BM from 2000 to 2014 at 17 institutions were retrospectively reviewed. OS was calculated from BM diagnosis. Median follow-up duration was 11.9 months (range, 0.1–126.2). Results: Median OS was 15.0 months (95% CI: 14.0–16.9). Patients with different BC-specific graded prognostic assessment (GPA) scores showed significant differences (p < 0.001) in OS. In multivariate analysis, histologic grade 3 (p = 0.014), presence of extracranial metastasis (p < 0.001), the number of BM (>4; p = 0.002), hormone receptor negativity (p = 0.005), HER2-negativity (p = 0.003), and shorter time interval (<30 months) between BC and BM diagnosis (p = 0.007) were associated with inferior OS. By summing the β-coefficients of variables that were prognostic in multivariate analyses, we developed a prognostic model that stratified patients into low-risk (≤0.673) and high-risk (>0.673) subgroups; the high-risk subgroup had poorer median OS (10.1 months, 95% CI: 7.9–11.9 vs. 21.9 months, 95% CI: 19.5–27.1, p < 0.001). Univariate and multivariate analyses of propensity score-matched patients diagnosed with BM ≥ 30 months after BC diagnosis (n = 389, “late BM”) revealed that WBRT-treated patients showed superior OS compared to non-WBRT-treated patients (p = 0.070 and 0.030, respectively). Conclusion: Our prognostic model identified high-risk BC patients with BM who might benefit from increased surveillance; if validated, our model could guide treatment selection for such patients. Patients with late BM might benefit from WBRT as initial local treatment. © 2019 Elsevier Ltd | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Churchill Livingstone | - |
dc.title | Survival outcomes of breast cancer patients with brain metastases: A multicenter retrospective study in Korea (KROG 16–12) | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.breast.2019.10.007 | - |
dc.identifier.bibliographicCitation | Breast, v.49, pp 41 - 47 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000512925000006 | - |
dc.identifier.scopusid | 2-s2.0-85074131659 | - |
dc.citation.endPage | 47 | - |
dc.citation.startPage | 41 | - |
dc.citation.title | Breast | - |
dc.citation.volume | 49 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스코트랜드 | - |
dc.subject.keywordAuthor | Brain metastasis | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Overall survival | - |
dc.subject.keywordAuthor | Prognostic model | - |
dc.subject.keywordAuthor | Whole brain radiotherapy | - |
dc.subject.keywordPlus | epidermal growth factor receptor 2 | - |
dc.subject.keywordPlus | hormone receptor | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | brain metastasis | - |
dc.subject.keywordPlus | breast cancer | - |
dc.subject.keywordPlus | cancer epidemiology | - |
dc.subject.keywordPlus | cancer grading | - |
dc.subject.keywordPlus | cancer prognosis | - |
dc.subject.keywordPlus | cancer surgery | - |
dc.subject.keywordPlus | cancer survival | - |
dc.subject.keywordPlus | clinical evaluation | - |
dc.subject.keywordPlus | clinical outcome | - |
dc.subject.keywordPlus | cohort analysis | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | high risk patient | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | immunohistochemistry | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | local therapy | - |
dc.subject.keywordPlus | low risk patient | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | medical record review | - |
dc.subject.keywordPlus | multicenter study (topic) | - |
dc.subject.keywordPlus | overall survival | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | prognostic assessment | - |
dc.subject.keywordPlus | radiation dose | - |
dc.subject.keywordPlus | retrospective study | - |
dc.subject.keywordPlus | whole brain radiotherapy | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.