Vitamin D supplementation does not prevent the recurrence of Graves’ disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho Y.Y. | - |
dc.contributor.author | Chung Y.J. | - |
dc.date.available | 2020-04-17T03:21:42Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38594 | - |
dc.description.abstract | Recent literature has reported a higher prevalence of vitamin D deficiency among people with Graves’ disease. No study has examined the effect of vitamin D supplementation on the clinical outcomes of Graves’ disease. We aimed to evaluate whether daily vitamin D supplementation reduces Graves’ disease recurrence. We enrolled 210 subjects with Graves’ disease and vitamin D deficiency and followed them for at least one year after anti-thyroid drug (ATD) discontinuation. Among 210 individuals, 60 (29%) were amenable to taking vitamin D supplements, resulting in sufficient vitamin D levels (from 10.6 to 25.7 ng/mL), whereas the mean vitamin D level was 11.6 ng/mL in the 150 patients who did not take vitamin D supplements. The recurrence rate was similar in both groups (38% vs. 49%, P = 0.086). However, recurrence occurred earlier in the latter group (7 months vs. 5 months, P = 0.016). In the multivariate analysis, vitamin D levels and TSH-binding inhibitory immunoglobulin (TBII) titers at ATD discontinuation remained significant factors for recurrence. Vitamin D levels and TBII titers at ATD discontinuation exhibited a weak negative correlation (R = −0.143, P = 0.041). Vitamin D supplementation might have a protective effect against Graves’ disease recurrence with a borderline significant recurrence rate reduction. © 2020, The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Research | - |
dc.title | Vitamin D supplementation does not prevent the recurrence of Graves’ disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-019-55107-9 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.10, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000511417900002 | - |
dc.identifier.scopusid | 2-s2.0-85077535099 | - |
dc.citation.number | 1 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | SERUM 25-HYDROXYVITAMIN D | - |
dc.subject.keywordPlus | FEMALE-PATIENTS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | KOREA | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.