Anti-viral activity of compounds from Agrimonia pilosa and Galla rhois extract mixture
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Jeong Eun | - |
dc.contributor.author | Lee, Yeong-Geun | - |
dc.contributor.author | Kang, Ji-Hun | - |
dc.contributor.author | Bai, Yun-Feng | - |
dc.contributor.author | Jeong, Yong Joon | - |
dc.contributor.author | Baek, Nam-In | - |
dc.contributor.author | Seo, Young-Jin | - |
dc.contributor.author | Kang, Se Chan | - |
dc.date.available | 2020-04-17T04:22:15Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.issn | 1090-2120 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38631 | - |
dc.description.abstract | Hepatitis C virus (HCV) infection is a significant health problem, with a worldwide prevalence of about 170 million. Recently, the development of direct acting antiviral (DAA) as a therapeutic agent for HCV has been rapidly increasing. However, DAA has a side effect and is costly. Therefore, it is still necessary to develop a therapeutic agent to treat HCV infection using products. Agrimonia pilosa (AP) and Galla rhois (RG) are traditional medicines and are known to display therapeutic activity on various diseases. Notably, they have been reported to have an anti-viral effect on HBV and influenza virus infections. It is expected that anti-viral activity will increase when two extracts are mixed. To investigate their anti-viral activity, the expression level of HCV Core 1b and NS5A was measured. Remarkably, AP, RG, and their mixed compound (APRG64) strongly inhibited the expression of viral proteins, which led us to identify their metabolites. A total of 14 metabolites were identified using liquid chromatography mass spectrometry (LC-MS). These metabolites were evaluated for their anti-HCV activity to identify active ingredients. In conclusion, our results unveiled that anti-HCV activity of Agrimonia pilosa and Galla rhois extract mixture could lead to the development of a novel therapy for HCV infection. © 2019 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press Inc. | - |
dc.title | Anti-viral activity of compounds from Agrimonia pilosa and Galla rhois extract mixture | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bioorg.2019.103320 | - |
dc.identifier.bibliographicCitation | Bioorganic Chemistry, v.93 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000499717000043 | - |
dc.identifier.scopusid | 2-s2.0-85072729545 | - |
dc.citation.title | Bioorganic Chemistry | - |
dc.citation.volume | 93 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Agrimonia pilosa | - |
dc.subject.keywordAuthor | Galla rhois | - |
dc.subject.keywordAuthor | HCV Core 1b | - |
dc.subject.keywordAuthor | LC-MS | - |
dc.subject.keywordAuthor | NS5A | - |
dc.subject.keywordPlus | C VIRUS-INFECTION | - |
dc.subject.keywordPlus | HEPATITIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GRAFT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.