High-Definition Chromoendoscopy Versus High-Definition White Light Colonoscopy for Neoplasia Surveillance in Ulcerative Colitis: A Randomized Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | Yang, Dong-Hoon | - |
dc.contributor.author | Park, Soo Jung | - |
dc.contributor.author | Kim, Hyun-Soo | - |
dc.contributor.author | Park, Young Sook | - |
dc.contributor.author | Park, Dong Il | - |
dc.contributor.author | Lee, Kang-Moon | - |
dc.contributor.author | Jung, Sung-Ae | - |
dc.contributor.author | Choi, Chang Hwan | - |
dc.contributor.author | Koo, Ja Seol | - |
dc.contributor.author | Cheon, Jae Hee | - |
dc.contributor.author | Yang, Suk-Kyun | - |
dc.contributor.author | Kim, Won Ho | - |
dc.contributor.author | Kim, Jihun | - |
dc.contributor.author | Kim, Hogeun | - |
dc.contributor.author | Ryan Choi, Chang-Ho | - |
dc.date.available | 2020-04-20T02:21:24Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1572-0241 | - |
dc.identifier.issn | 1572-0241 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38718 | - |
dc.description.abstract | OBJECTIVES: Although chromoendoscopy is currently the recommended mode of surveillance in patients with long-standing ulcerative colitis, it is technically challenging and requires a long procedure time. The aim of this study was to compare the dysplasia detection rate of high-definition white light endoscopy with random biopsy (HDWL-R) vs high-definition chromoendoscopy with targeted biopsy (HDCE-T). METHODS: This was a multicenter, prospective randomized controlled trial involving 9 tertiary teaching hospitals in South Korea. A total of 210 patients with long-standing ulcerative colitis were randomized to undergo either the HDWL-R group (n = 102) or HDCE-T group (n = 108). The detection rates of colitis-associated dysplasia (CAD) or all colorectal neoplasia from each trial arm were compared. RESULTS: There was no significant difference in the CAD detection rate between HDCE-T and HDWL-R groups (4/102, 3.9% vs 6/108, 5.6%, P = 0.749). However, HDCE-T showed a trend toward improved colorectal neoplasia detection compared with HDWL-R (21/102, 20.6% vs 13/108, 12.0%, P = 0.093). The median (range) time for colonoscopy withdrawal between the 2 groups was similar (17.6 [7.0-43.3] minutes vs 16.5 [6.3-38.1] minutes; P=0.212; for HDWL-R and HDCE-T, respectively). The total number of biopsies was significantly larger in the HDWL-R group (34 [12-72]) compared with the HDCE-T group (9 [1-20]; P < 0.001). DISCUSSION: On the basis of our prospective randomized controlled trial, HDCE-T was not superior to HDWL-R for detecting CADs. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | High-Definition Chromoendoscopy Versus High-Definition White Light Colonoscopy for Neoplasia Surveillance in Ulcerative Colitis: A Randomized Controlled Trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.14309/ajg.0000000000000341 | - |
dc.identifier.bibliographicCitation | The American journal of gastroenterology, v.114, no.10, pp 1642 - 1648 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000497321600013 | - |
dc.identifier.scopusid | 2-s2.0-85072944586 | - |
dc.citation.endPage | 1648 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1642 | - |
dc.citation.title | The American journal of gastroenterology | - |
dc.citation.volume | 114 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | INTRAEPITHELIAL NEOPLASIA | - |
dc.subject.keywordPlus | DETECTING DYSPLASIA | - |
dc.subject.keywordPlus | DIAGNOSTIC YIELD | - |
dc.subject.keywordPlus | RANDOM BIOPSIES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PROGRAM | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | INCREASES | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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