Serum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans
DC Field | Value | Language |
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dc.contributor.author | Kim, Won-Young | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.contributor.author | Kim, Dong-Young | - |
dc.contributor.author | Ryu, Hyun Jin | - |
dc.contributor.author | Chon, Gyu Rak | - |
dc.contributor.author | Park, Yun Young | - |
dc.contributor.author | Fu, Yan | - |
dc.contributor.author | Huh, Jin Won | - |
dc.contributor.author | Lim, Chae-Man | - |
dc.contributor.author | Koh, Younsuck | - |
dc.contributor.author | Choi, Eun Young | - |
dc.contributor.author | Hong, Sang-Bum | - |
dc.date.available | 2020-04-20T02:22:51Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38742 | - |
dc.description.abstract | Disruption of the endothelial glycocalyx has a prominent role in the pathophysiology of sepsis. Developmental endothelial locus-1 (Del-1) is an endothelial-derived anti-inflammatory factor. We hypothesized that degradation of the endothelial glycocalyx during sepsis may increase serum Del-1. A mouse model of sepsis was created using cecal ligation and puncture. In septic mice, the endothelial glycocalyx was nearly completely degraded, with less formation of Del-1 in the endothelium and extracellular matrix than in control mice. Serum Del-1 levels were significantly increased in the septic mice with increasing severity of sepsis. Serum Del-1 levels were also measured in 84 patients with sepsis and septic shock and in 20 control subjects. The median serum Del-1 level in patients with sepsis was significantly higher than that in healthy controls. The high Del-1 group had higher illness severity scores and contained more patients with organ dysfunction than the low Del-1 group. The 90-day mortality rate was significantly higher in the high Del-1 group than in the low Del-1 group. Multivariate analysis indicated a tendency for a high serum Del-1 level to be associated with a higher mortality risk. Increased serum Del-1 may be a novel diagnostic biomarker of sepsis and an indicator of disease severity. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Serum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-019-49564-5 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000484986300019 | - |
dc.identifier.scopusid | 2-s2.0-85072036893 | - |
dc.citation.number | 1 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | RESPIRATORY-DISTRESS-SYNDROME | - |
dc.subject.keywordPlus | SEPTIC SHOCK | - |
dc.subject.keywordPlus | ADRENAL INSUFFICIENCY | - |
dc.subject.keywordPlus | CRITICALLY-ILL | - |
dc.subject.keywordPlus | ORGAN FAILURE | - |
dc.subject.keywordPlus | DEL-1 | - |
dc.subject.keywordPlus | GLYCOCALYX | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MICROPARTICLES | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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