Validation of a New Point Shear-Wave Elastography Method for Noninvasive Assessment of Liver Fibrosis: A Prospective Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | Joo, Ijin | - |
dc.contributor.author | Kim, So Yeon | - |
dc.contributor.author | Park, Hee Sun | - |
dc.contributor.author | Lee, Eun Sun | - |
dc.contributor.author | Kang, Hyo Jeong | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.date.available | 2020-04-21T06:20:32Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.issn | 2005-8330 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38880 | - |
dc.description.abstract | Objective: To validate the diagnostic value of a new point shear-wave elastography method, S-shearwave elastography (S-SWE; Samsung Medison Co., Ltd.), in noninvasive assessment of liver fibrosis. Materials and Methods: In this prospective multicenter study, liver stiffness (LS) measurements for 600 participants were obtained with both S-SWE and transient elastography (TE). The rates of unsuccessful LS measurements in S-SWE and TE were compared, and correlations between S-SWE and TE measurements were assessed. In 107 patients with histologic reference data, the optimal LS cut-off values for predicting severe fibrosis and cirrhosis on S-SWE were determined using receiver operating characteristic (ROC) curve analysis. The LS cut-off values in S-SWE were then validated in 463 patients without histologic reference data by using TE values as the reference standard, and the sensitivity and specificity of the cut-off values for predicting severe fibrosis and cirrhosis were calculated. Results: The frequency of unsuccessful LS measurements on TE (4.5%, 27/600) was significantly higher than that (0.7%, 4/600) on S-SWE (p < 0.001). LS measurements on S-SWE showed a significant correlation with TE values (r = 0.880, p < 0.001). In 107 patients with histological reference data, the areas under the ROC curves on S-SWE were 0.845 and 0.850, with optimal cut-offs of 7.0 kilopascals (kPa) and 9.7 kPa, for the diagnosis of severe fibrosis and cirrhosis, respectively. Using these cut-off values, S-SWE showed sensitivities of 92.9% and 97.4% and specificities of 89.5% and 83.1% in TE-based evaluations of severe fibrosis and cirrhosis, respectively. Conclusion: LS measurements on S-SWE were well correlated with those on TE. In addition, S-SWE provided good diagnostic performance for staging of hepatic fibrosis, with a lower rate of unsuccessful LS measurements compared with TE. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN RADIOLOGICAL SOC | - |
dc.title | Validation of a New Point Shear-Wave Elastography Method for Noninvasive Assessment of Liver Fibrosis: A Prospective Multicenter Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.3348/kjr.2019.0109 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, v.20, no.11, pp 1527 - 1535 | - |
dc.identifier.kciid | ART002515108 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000489731500005 | - |
dc.identifier.scopusid | 2-s2.0-85073155801 | - |
dc.citation.endPage | 1535 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1527 | - |
dc.citation.title | KOREAN JOURNAL OF RADIOLOGY | - |
dc.citation.volume | 20 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Ultrasound | - |
dc.subject.keywordAuthor | Elastography | - |
dc.subject.keywordAuthor | Validation | - |
dc.subject.keywordAuthor | Liver | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.subject.keywordPlus | IMPULSE ARFI ELASTOGRAPHY | - |
dc.subject.keywordPlus | TRANSIENT ELASTOGRAPHY | - |
dc.subject.keywordPlus | ULTRASOUND ELASTOGRAPHY | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | DIAGNOSTIC PERFORMANCE | - |
dc.subject.keywordPlus | REPRODUCIBILITY | - |
dc.subject.keywordPlus | HEPATITIS | - |
dc.subject.keywordPlus | STIFFNESS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | RELIABILITY | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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