Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by d-amphetamine
DC Field | Value | Language |
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dc.contributor.author | Tran H.-Q. | - |
dc.contributor.author | Shin E.-J. | - |
dc.contributor.author | Saito K. | - |
dc.contributor.author | Tran T.-V. | - |
dc.contributor.author | Phan D.-H. | - |
dc.contributor.author | Sharma N. | - |
dc.contributor.author | Kim D.-W. | - |
dc.contributor.author | Choi S.Y. | - |
dc.contributor.author | Jeong J.H. | - |
dc.contributor.author | Jang C.-G. | - |
dc.contributor.author | Cheong J.H. | - |
dc.contributor.author | Nabeshima T. | - |
dc.contributor.author | Kim H.-C. | - |
dc.date.available | 2020-04-22T06:21:26Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.issn | 1873-6351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38947 | - |
dc.description.abstract | It is recognized that d-amphetamine (AMPH)-induced hyperactivity is thought to be a valid animal model of mania. In the present study, we investigated whether a proinflammatory oxidative gene indoleamine-2,3-dioxygenase (IDO) is involved in AMPH-induced mitochondrial burden, and whether mood stabilizers (i.e., lithium and valproate) modulate IDO to protect against AMPH-induced mania-like behaviors. AMPH-induced IDO-1 expression was significantly greater than IDO-2 expression in the prefrontal cortex of wild type mice. IDO-1 expression was more pronounced in the mitochondria than in the cytosol. AMPH treatment activated intra-mitochondrial Ca2+ accumulation and mitochondrial oxidative burden, while inhibited mitochondrial membrane potential and activity of the mitochondrial complex (I > II), mitochondrial glutathione peroxidase, and superoxide dismutase, indicating that mitochondrial burden might be contributable to mania-like behaviors induced by AMPH. The behaviors were significantly attenuated by lithium, valproate, or IDO-1 knockout, but not in IDO-2 knockout mice. Lithium, valproate administration, or IDO-1 knockout significantly attenuated mitochondrial burden. Neither lithium nor valproate produced additive effects above the protective effects observed in IDO-1 KO in mice. Collectively, our results suggest that mood stabilizers attenuate AMPH-induced mania-like behaviors via attenuation of IDO-1-dependent mitochondrial stress, highlighting IDO-1 as a novel molecular target for the protective potential of mood stabilizers. © 2019 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by d-amphetamine | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fct.2019.110986 | - |
dc.identifier.bibliographicCitation | Food and Chemical Toxicology, v.136 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000514015300028 | - |
dc.identifier.scopusid | 2-s2.0-85076212108 | - |
dc.citation.title | Food and Chemical Toxicology | - |
dc.citation.volume | 136 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | d-amphetamine-induced mania-like behavior | - |
dc.subject.keywordAuthor | IDO-1 knockout mice | - |
dc.subject.keywordAuthor | IDO-2 knockout mice | - |
dc.subject.keywordAuthor | Mitochondrial stress | - |
dc.subject.keywordAuthor | Mood stabilizer | - |
dc.subject.keywordAuthor | Oxidative burden | - |
dc.subject.keywordPlus | ELECTRON-TRANSPORT CHAIN | - |
dc.subject.keywordPlus | DELTA KNOCKOUT MICE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INDOLEAMINE 2,3-DIOXYGENASE | - |
dc.subject.keywordPlus | BIPOLAR DISORDER | - |
dc.subject.keywordPlus | ANIMAL-MODEL | - |
dc.subject.keywordPlus | MITOCHONDRIAL DYSFUNCTION | - |
dc.subject.keywordPlus | TRYPTOPHAN 2,3-DIOXYGENASE | - |
dc.subject.keywordPlus | GLUTATHIONE PEROXIDASE-1 | - |
dc.subject.keywordPlus | CELLULAR PLASTICITY | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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