Memory performance associates with serotonin transporter in midbrain and pons in healthy subjects
DC Field | Value | Language |
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dc.contributor.author | Pak, Kyoungjune | - |
dc.contributor.author | Shin, Seunghyeon | - |
dc.contributor.author | Kim, Keunyoung | - |
dc.contributor.author | Seok, Ju Won | - |
dc.contributor.author | Kim, Seong Jang | - |
dc.contributor.author | Kim, In Joo | - |
dc.date.available | 2020-04-23T07:20:04Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 1790-5427 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38973 | - |
dc.description.abstract | Objective: We aimed to evaluate the association between the availability of serotonin transporter (SERT) measured by ioflupane-DaTSCAN (I-123-FP-CIT) and imaged by single photon emission tomography (SPET) and memory function in healthy subjects. Subjects and Methods: Specific binding of I-123-FP-CST indicating SERT was achieved using a region of interest analysis. Spherical volumes of interest for midbrain and pons were defined. The cerebellum was chosen as a reference region. Specific binding ratios (SBR) in midbrain and pons representing SERT availability were measured as follows: SBR=(target-cerebellum)/cerebellum. A hundred and eighty-one healthy subjects (117 male, 64 female) were included in this study. Results: Specific binding ratios of both midbrain (P=0.025) and pons (P=0.006) of males was higher than that of females. None of the SBR showed a correlation with age both in males: (midbrain; P=0.736, pons; P=0.875) and in females (midbrain; P=0.294, pons; P=0.170). In all our cases, SERT availability of midbrain correlated positively with total recall score (rho=0.159, P=0.033), and delayed recall score (rho=0.149, P=0.046). In females, the correlation between SERT availability in midbrain and delayed recall score was significant (rho=0.320, P=0.010), however, not in males (rho=0.112, P=0.229). Conclusion: In conclusion, we demonstrated that SERT availability was associated with memory function in healthy females from the PPMI database. Further studies are needed to clarify underlying mechanisms of this phenomenon. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | HELLENIC SOC NUCLEAR MEDICINE | - |
dc.title | Memory performance associates with serotonin transporter in midbrain and pons in healthy subjects | - |
dc.type | Article | - |
dc.identifier.doi | 10.1967/s002449911055 | - |
dc.identifier.bibliographicCitation | HELLENIC JOURNAL OF NUCLEAR MEDICINE, v.22, no.3, pp 194 - 199 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000506147400006 | - |
dc.identifier.scopusid | 2-s2.0-85074184378 | - |
dc.citation.endPage | 199 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 194 | - |
dc.citation.title | HELLENIC JOURNAL OF NUCLEAR MEDICINE | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 그리이스 | - |
dc.subject.keywordAuthor | Memory | - |
dc.subject.keywordAuthor | Serotonin plasma membrane transporter proteins | - |
dc.subject.keywordAuthor | I-123-FP-CT | - |
dc.subject.keywordAuthor | Brain | - |
dc.subject.keywordAuthor | SPET imaging | - |
dc.subject.keywordPlus | VERBAL-LEARNING TEST | - |
dc.subject.keywordPlus | NORMATIVE DATA | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | SEX-DIFFERENCES | - |
dc.subject.keywordPlus | BRAIN DOPAMINE | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | SPECT | - |
dc.subject.keywordPlus | ECSTASY | - |
dc.subject.keywordPlus | USERS | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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