The change in the nationwide seroprevalence of hepatitis C virus and the status of linkage to care in South Korea from 2009 to 2015
- Authors
- Jang, Eun Sun; Ki, Moran; Choi, Hwa Young; Kim, Kyung-Ah; Jeong, Sook-Hyang; Gwak, Geum-Youn; Kim, Gi-Ae; Kim, Do Young; Kim, Dong Joon; Kim, Man Woo; Kim, Sung Eun; Kim, Yun Soo; Kim, Young Seok; Kim, In Hee; Kim, Chang Wook; Kim, Ho Dong; Kim, Hyung Joon; Park, Neung Hwa; Baik, Soon Koo; Suh, Jeong Ill; Song, Byung-Cheol; Song, Il Han; Yeon, Jong Eun; Lee, Byung Seok; Lee, Youn Jae; Jung, Young Kul; Chung, Woo Jin; Cho, Sung Bum; Cho, Eun-Young; Cho, Hyun Chin; Cheon, Gab Jin; Chae, Hee Bok; Choi, Dae Hee; Choi, Sung-Kyu; Tak, Won Young; Heo, Jeong
- Issue Date
- Sep-2019
- Publisher
- SPRINGER
- Keywords
- Hepatitis C virus; Epidemiology; Prevalence; Anti-HCV; HCV RNA; Antiviral treatment
- Citation
- HEPATOLOGY INTERNATIONAL, v.13, no.5, pp 599 - 608
- Pages
- 10
- Journal Title
- HEPATOLOGY INTERNATIONAL
- Volume
- 13
- Number
- 5
- Start Page
- 599
- End Page
- 608
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38990
- DOI
- 10.1007/s12072-019-09975-y
- ISSN
- 1936-0533
1936-0541
- Abstract
- Background Hepatitis C virus (HCV) requires epidemiological monitoring to estimate its disease burden and to develop countermeasures. This study aimed to investigate the difference between the 2015 and 2009 nationwide anti-HCV seroprevalence and to determine linkage to care estimates in South Korea. Methods A total 268,422 examinees >= 20 years old were included in 2015 from 33 medical institutions nationwide. Electronically extracted data were retrospectively analyzed to calculate the age-, sex-, and area-adjusted anti-HCV prevalence. Seroprevalence in 2015 was measured using the same method as that in 2009. For anti-HCV-positive subjects, medical records were reviewed to see whether HCV RNA testing or antiviral treatment was performed. Results Adjusted anti-HCV prevalence was 0.60% (95% confidence interval, 0.57-0.63) based on general Korean population in 2015. It showed an increasing trend according to age; 0.23% in thirties, 0.38% in forties, 0.63% in fifties, 1.08% in sixties, and 1.65% in those aged >= 70 years. From 2009 to 2015, the adjusted anti-HCV prevalence decreased by 30%, with odds ratio of 0.70 (95% CI 0.70-0.71). There was significant intranational regional variation and changing pattern of seroprevalence. Among 1359 anti-HCV-positive subjects, HCV RNA test was performed in 60% and 25.4% had positivity. Treatment-initiated and cured rates in 2015 were 18.5% and 10.9%, respectively. Conclusions Anti-HCV prevalence in South Korea was 0.6% in 2015, showing a 30% decrease from that in 2009. Although the HCV RNA testing rate was increased since 2009, this remains suboptimal. Moreover, the treatment uptake rate should be improved in South Korea.
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