Anti-inflammatory effects of phenolic compounds isolated from Quercus mongolica Fisch. Ex Ledeb. On UVB-irradiated human skin cells
DC Field | Value | Language |
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dc.contributor.author | Yin, J. | - |
dc.contributor.author | Kim, H.H. | - |
dc.contributor.author | Hwang, I.H. | - |
dc.contributor.author | Kim, D.H. | - |
dc.contributor.author | Lee, M.W. | - |
dc.date.available | 2020-04-23T08:21:48Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38996 | - |
dc.description.abstract | Quercus mongolica Fisch. ex Ledeb. (QM) has been used as an oriental traditional medicine to relieve hemorrhoids, fever, and enteritis. We screened the inhibitory activities of the extracts and compounds (1–6) isolated from QM on the production of inflammatory cytokines and chemokines to evaluate their anti-inflammatory activities. Further, we evaluated the expression levels of cytokines, chemokines, and immune factors on pedunculagin (PC, 1), which was selected from isolated compounds (1–6) because of its potential anti-inflammation effect. Additionally, we evaluated whether the inflammation mitigation effects of PC (1) following UVB exposure in keratinocytes occurred because of nuclear factor (NF)-κB and signal transducer and activator of transcription (STAT)/Janus kinase (JAK) activation. PC (1) remarkably suppressed interleukin (IL)-6, IL-10, IL-13, and monocyte chemoattractant protein-1 (MCP-1) mRNA expression and reduced the mRNA expression level of Cyclooxygenase-2 (COX-2) and also reduced the phosphorylation of p38 mitogen-activated protein kinases (p38), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) in a concentration-dependent manner. © 2019 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Anti-inflammatory effects of phenolic compounds isolated from Quercus mongolica Fisch. Ex Ledeb. On UVB-irradiated human skin cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/molecules24173094 | - |
dc.identifier.bibliographicCitation | Molecules, v.24, no.17 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000488613700074 | - |
dc.identifier.scopusid | 2-s2.0-85071440340 | - |
dc.citation.number | 17 | - |
dc.citation.title | Molecules | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Pedunculagin | - |
dc.subject.keywordAuthor | Quercus mongolica Fisch. ex Ledeb | - |
dc.subject.keywordAuthor | Skin inflammation disease | - |
dc.subject.keywordPlus | ACTIVATION-REGULATED CHEMOKINE | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TARC/CCL17 PRODUCTION | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | TH2 CYTOKINES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | THYMUS | - |
dc.subject.keywordPlus | PSORIASIS | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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