Chemotactic migration of newly excysted juvenile Clonorchis sinensis is suppressed by neuro-antagonists
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Shunyu | - |
dc.contributor.author | Song, Jin-Ho | - |
dc.contributor.author | Kim, Tae Im | - |
dc.contributor.author | Yoo, W.G. | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.contributor.author | Dai, Fuhong | - |
dc.contributor.author | Hong, Sung-Jong | - |
dc.date.available | 2020-04-23T08:23:19Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 1935-2735 | - |
dc.identifier.issn | 1935-2735 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/39020 | - |
dc.description.abstract | The metacercariae of the Clonorchis sinensis liver fluke excyst in the duodenum of mammalian hosts, and the newly excysted juveniles (CsNEJs) migrate along the bile duct via bile chemotaxis. Cholic acid is a major component of bile that induces this migration. We investigated the neuronal control of chemotactic behavior of CsNEJs toward cholic acid. The migration of CsNEJs was strongly inhibited at sub-micromolar concentration by dopamine D1 (LE-300 and SKF-83566), D2 (spiramide, nemonapride, and sulpiride), and D3 (GR-103691 and NGB-2904) receptor antagonists, as well as a dopamine reuptake inhibitor (BTCP). Neuropeptides, FMRFamide, peptide YY, and neuropeptide Y were also potent inhibitors of chemotaxis. Meanwhile, serotonergic, glutamatergic, and cholinergic inhibitors did not affect chemotaxis, with the exception of fluoxetine and CNQX. Confocal immunofluorescence analysis indicated that dopaminergic and cholinergic neurons were colocalized in the somatic muscle tissues of adult C. sinensis. Our findings suggest that dopaminergic neurons and neuropeptides play a major role in the chemotactic migration of CsNEJs to bile, and their inhibitors or modulators could be utilized to prevent their migration from the bile duct. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | Chemotactic migration of newly excysted juvenile Clonorchis sinensis is suppressed by neuro-antagonists | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pntd.0007573 | - |
dc.identifier.bibliographicCitation | PLoS neglected tropical diseases, v.13, no.8 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000490919400023 | - |
dc.identifier.scopusid | 2-s2.0-85071281863 | - |
dc.citation.number | 8 | - |
dc.citation.title | PLoS neglected tropical diseases | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | SCHISTOSOMA-MANSONI | - |
dc.subject.keywordPlus | FASCIOLA-HEPATICA | - |
dc.subject.keywordPlus | TYROSINE-HYDROXYLASE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | MOTILITY | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | ACETYLCHOLINE | - |
dc.subject.keywordPlus | TREMATODE | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalResearchArea | Tropical Medicine | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Tropical Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.