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Development of a mel cell-derived allograft mouse model for cancer research

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dc.contributor.authorKim, Min Young-
dc.contributor.authorChoi, Sungwoo-
dc.contributor.authorLee, Seol Eui-
dc.contributor.authorKim, Ji Sook-
dc.contributor.authorSon, Seung Han-
dc.contributor.authorLim, Young Soo-
dc.contributor.authorKim, Bang-Jin-
dc.contributor.authorRyu, Buom-Yong-
dc.contributor.authorUversky, Vladimir N.-
dc.contributor.authorLee, Young Jin-
dc.contributor.authorKim, Chul Geun-
dc.date.available2020-04-24T02:21:12Z-
dc.date.issued2019-11-
dc.identifier.issn2072-6694-
dc.identifier.issn2072-6694-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/39067-
dc.description.abstractMurine erythroleukemia (MEL) cells are often employed as a model to dissect mechanisms of erythropoiesis and erythroleukemia in vitro. Here, an allograft model using MEL cells resulting in splenomegaly was established to develop a diagnostic model for isolation/quantification of metastatic cells, anti-cancer drug screening, and evaluation of the tumorigenic or metastatic potentials of molecules in vivo. In this animal model, circulating MEL cells from the blood stream were successfully isolated and quantified with an additional in vitro cultivation step. In terms of the molecular-pathological analysis, we were able to successfully evaluate the functional discrimination between methyl-CpG-binding domain 2 (Mbd2) and p66α in erythroid differentiation, and tumorigenic potential in spleen and blood stream of allograft model mice. In addition, we found that the number of circulating MEL cells in anti-cancer drug-treated mice was dose-dependently decreased. Our data demonstrate that the newly established allograft model is useful to dissect erythroleukemia pathologies and non-invasively provides valuable means for isolation of metastatic cells, screening of anti-cancer drugs, and evaluation of the tumorigenic potentials. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.-
dc.language영어-
dc.language.isoENG-
dc.publisherMDPI AG-
dc.titleDevelopment of a mel cell-derived allograft mouse model for cancer research-
dc.typeArticle-
dc.identifier.doi10.3390/cancers11111707-
dc.identifier.bibliographicCitationCancers, v.11, no.11-
dc.description.isOpenAccessY-
dc.identifier.wosid000502290100089-
dc.identifier.scopusid2-s2.0-85074614404-
dc.citation.number11-
dc.citation.titleCancers-
dc.citation.volume11-
dc.type.docTypeArticle-
dc.publisher.location스위스-
dc.subject.keywordAuthorAllograft-
dc.subject.keywordAuthorCancer treatment-
dc.subject.keywordAuthorCirculating tumor cells-
dc.subject.keywordAuthorErythroleukemia-
dc.subject.keywordAuthorLiquid biopsy-
dc.subject.keywordPlusfluorouracil-
dc.subject.keywordPlushexamethylenebisacetamide-
dc.subject.keywordPlusmethyl CpG binding protein 2-
dc.subject.keywordPlusprotein p66-
dc.subject.keywordPlusallograft-
dc.subject.keywordPlusanimal cell-
dc.subject.keywordPlusanimal experiment-
dc.subject.keywordPlusanimal model-
dc.subject.keywordPlusanimal tissue-
dc.subject.keywordPlusArticle-
dc.subject.keywordPluscancer research-
dc.subject.keywordPluscarcinogenicity-
dc.subject.keywordPluscell differentiation-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPlusdrug screening-
dc.subject.keywordPluserythroid cell-
dc.subject.keywordPluserythroleukemia-
dc.subject.keywordPluserythroleukemia cell-
dc.subject.keywordPlusmetastasis potential-
dc.subject.keywordPlusmouse-
dc.subject.keywordPlusnonhuman-
dc.subject.keywordPlusprotein analysis-
dc.subject.keywordPlusrandomized controlled trial-
dc.subject.keywordPlusRNA interference-
dc.subject.keywordPlussplenomegaly-
dc.relation.journalResearchAreaOncology-
dc.relation.journalWebOfScienceCategoryOncology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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