Gemcitabine plus carboplatin versus gemcitabine plus oxaliplatin in cisplatin-unfit patients with advanced urothelial carcinoma: a randomised phase II study (COACH, KCSG GU10-16)
DC Field | Value | Language |
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dc.contributor.author | Park, Inkeun | - |
dc.contributor.author | Kim, Bong-Seog | - |
dc.contributor.author | Lim, Ho Yeong | - |
dc.contributor.author | Kim, Hee-Jun | - |
dc.contributor.author | Lee, Hyo Jin | - |
dc.contributor.author | Choi, Yoon Ji | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Lee, Kyung Hee | - |
dc.contributor.author | Yoon, Shinkyo | - |
dc.contributor.author | Hong, Bumsik | - |
dc.contributor.author | Hong, Jun Hyuk | - |
dc.contributor.author | Ahn, H. | - |
dc.contributor.author | Lee, Jae Lyun. | - |
dc.date.available | 2020-04-24T03:20:09Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0959-8049 | - |
dc.identifier.issn | 1879-0852 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/39076 | - |
dc.description.abstract | Purpose: Gemcitabine–oxaliplatin (GEMOX) demonstrated mild toxicity and promising effectiveness in patients with advanced urothelial cell cancer (UCC). We investigated the activity and safety of first-line GEMOX compared with gemcitabine–carboplatin (GCb) in cisplatin-ineligible patients with advanced UCC. Methods: Treatment-naive, cisplatin-ineligible patients with advanced UCC were randomly assigned to GEMOX (gemcitabine 1000 mg/m2, oxaliplatin 100 mg/m2 on day 1 [D1] every 2 weeks) or GCb (1000 mg/m2 of gemcitabine on D1 and D8 and carboplatin area under the curve of 4.5 mg/mL/min on D1 every 3 weeks). We evaluated the objective response rate (ORR), progression-free survival (PFS) and overall survival (OS). Results: Between January 2011 and March 2017, 80 patients were enrolled; 39 and 40 patients were allocated to GCb and GEMOX arms, respectively. The ORR was 48.7% in the GCb arm and 55.0% in the GEMOX arm. The median follow-up duration was 37.8 months; the median PFS and OS in the GCb and GEMOX arms were 5.5 months (95% confidence interval [CI], 4.8–6.2) vs. 4.4 months (95% CI, 2.7–6.1) and 9.1 months (95% CI, 5.2–13.0) vs. 11.0 months (95% CI, 6.9–15.0), respectively. ≥Leucopenia, neutropenia and fatigue of ≥ grade III were significantly more common in the GCb arm (26% vs. 3%, P = 0.003; 33% vs. 10%, P = 0.014; 15% vs. 3%, P = 0.012), whereas any-grade neuropathy was more common in the GEMOX arm (8% vs. 60%). Conclusions: GEMOX showed similar efficacy with GCb and a favourable haematologic toxicity profile. GEMOX may be an additional chemotherapy option for patients with UCC ineligible for cisplatin-containing chemotherapy (NCT01487915). © 2019 Elsevier Ltd | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Gemcitabine plus carboplatin versus gemcitabine plus oxaliplatin in cisplatin-unfit patients with advanced urothelial carcinoma: a randomised phase II study (COACH, KCSG GU10-16) | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejca.2019.08.034 | - |
dc.identifier.bibliographicCitation | European Journal of Cancer, v.127, pp 183 - 190 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000514572100019 | - |
dc.identifier.scopusid | 2-s2.0-85074427378 | - |
dc.citation.endPage | 190 | - |
dc.citation.startPage | 183 | - |
dc.citation.title | European Journal of Cancer | - |
dc.citation.volume | 127 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Carboplatin | - |
dc.subject.keywordAuthor | Cisplatin-unfit | - |
dc.subject.keywordAuthor | Gemcitabine | - |
dc.subject.keywordAuthor | Oxaliplatin | - |
dc.subject.keywordAuthor | Urothelial cancer | - |
dc.subject.keywordPlus | TRANSITIONAL-CELL CARCINOMA | - |
dc.subject.keywordPlus | 1ST-LINE TREATMENT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | METHOTREXATE | - |
dc.subject.keywordPlus | VINBLASTINE | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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