Butyrate attenuated fat gain through gut microbiota modulation in db/db mice following dapagliflozin treatment
DC Field | Value | Language |
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dc.contributor.author | Oh, Tae Jung | - |
dc.contributor.author | Sul , Woo Jun | - |
dc.contributor.author | Oh, Han Na | - |
dc.contributor.author | Lee, Yun-Kyung | - |
dc.contributor.author | Lim, Hye Li | - |
dc.contributor.author | Choi, Sung Hee | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Jang, Hak Chul | - |
dc.date.available | 2020-05-12T11:34:38Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/39368 | - |
dc.description.abstract | We investigated the effect of a combination treatment with dapagliflozin (Dapa), a sodium-glucose cotransporter-2 inhibitor and butyrate on weight change in db/db mice. Six-week-old male db/db mice were assigned to four groups: vehicle with normal chow diet (NCD), Dapa with NCD, vehicle with 5% sodium butyrate-supplemented NCD (NaB), or Dapa with 5% NaB. After six weeks of treatment, faecal microbiota composition was analysed by sequencing 16S ribosomal RNA genes. In the vehicle with NaB and Dapa + NaB groups, body weight increase was attenuated, and amount of food intake decreased compared with the vehicle with the NCD group. The Dapa + NaB group gained the least total and abdominal fat from baseline. Intestinal microbiota of this group was characterized by a decrease of the Firmicutes to Bacteroidetes ratio, a decrease of Adlercreutzia and Alistipes, as well as an increase of Streptococcus. In addition, the proportion of Adlercreutzia and Alistipes showed a positive correlation with total fat gain, whereas Streptococcus showed a negative correlation. Inferred metagenome function revealed that tryptophan metabolism was upregulated by NaB treatment. We demonstrated a synergistic effect of Dapa and NaB treatment on adiposity reduction, and this phenomenon might be related to intestinal microbiota alteration. © 2019, The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Research | - |
dc.title | Butyrate attenuated fat gain through gut microbiota modulation in db/db mice following dapagliflozin treatment | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-019-56684-5 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.9, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000508984900019 | - |
dc.identifier.scopusid | 2-s2.0-85077210849 | - |
dc.citation.number | 1 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | WEIGHTGLUCOSEOBESITYACIDSDIETMETABOLITESASSOCIATIONHOMEOSTASISINHIBITIONSEROTONIN | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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