Phosphorylation dynamics of jnk signaling: Effects of dual-specificity phosphatases (dusps) on the jnk pathway
DC Field | Value | Language |
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dc.contributor.author | Ha J. | - |
dc.contributor.author | Kang E. | - |
dc.contributor.author | Seo J. | - |
dc.contributor.author | Cho S. | - |
dc.date.available | 2020-05-12T11:35:01Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/39374 | - |
dc.description.abstract | Protein phosphorylation affects conformational change, interaction, catalytic activity, and subcellular localization of proteins. Because the post-modification of proteins regulates diverse cellular signaling pathways, the precise control of phosphorylation states is essential for maintaining cellular homeostasis. Kinases function as phosphorylating enzymes, and phosphatases dephosphorylate their target substrates, typically in a much shorter time. The c-Jun N-terminal kinase (JNK) signaling pathway, a mitogen-activated protein kinase pathway, is regulated by a cascade of kinases and in turn regulates other physiological processes, such as cell differentiation, apoptosis, neuronal functions, and embryonic development. However, the activation of the JNK pathway is also implicated in human pathologies such as cancer, neurodegenerative diseases, and inflammatory diseases. Therefore, the proper balance between activation and inactivation of the JNK pathway needs to be tightly regulated. Dual specificity phosphatases (DUSPs) regulate the magnitude and duration of signal transduction of the JNK pathway by dephosphorylating their substrates. In this review, we will discuss the dynamics of phosphorylation/dephosphorylation, the mechanism of JNK pathway regulation by DUSPs, and the new possibilities of targeting DUSPs in JNK-related diseases elucidated in recent studies. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Phosphorylation dynamics of jnk signaling: Effects of dual-specificity phosphatases (dusps) on the jnk pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms20246157 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.20, no.24 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000506840100052 | - |
dc.identifier.scopusid | 2-s2.0-85076269097 | - |
dc.citation.number | 24 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 20 | - |
dc.type.docType | Review | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | C-Jun N-terminal kinase pathway | - |
dc.subject.keywordAuthor | Dephosphorylation | - |
dc.subject.keywordAuthor | Dual-specificity phosphatase | - |
dc.subject.keywordAuthor | Mitogen-activated protein kinase pathway | - |
dc.subject.keywordPlus | activating transcription factor 2 | - |
dc.subject.keywordPlus | amyloid beta protein | - |
dc.subject.keywordPlus | caspase 3 | - |
dc.subject.keywordPlus | dual specificity phosphatase | - |
dc.subject.keywordPlus | dual specificity phosphatase 10 | - |
dc.subject.keywordPlus | dual specificity phosphatase 11 | - |
dc.subject.keywordPlus | dual specificity phosphatase 14 | - |
dc.subject.keywordPlus | dual specificity phosphatase 16 | - |
dc.subject.keywordPlus | dual specificity phosphatase 19 | - |
dc.subject.keywordPlus | dual specificity phosphatase 2 | - |
dc.subject.keywordPlus | dual specificity phosphatase 22 | - |
dc.subject.keywordPlus | dual specificity phosphatase 23 | - |
dc.subject.keywordPlus | dual specificity phosphatase 3 | - |
dc.subject.keywordPlus | dual specificity phosphatase 4 | - |
dc.subject.keywordPlus | dual specificity phosphatase 6 | - |
dc.subject.keywordPlus | dual specificity phosphatase 7 | - |
dc.subject.keywordPlus | dual specificity phosphatase 9 | - |
dc.subject.keywordPlus | G protein coupled receptor | - |
dc.subject.keywordPlus | glutamic acid | - |
dc.subject.keywordPlus | glycine | - |
dc.subject.keywordPlus | mitogen activated protein kinase | - |
dc.subject.keywordPlus | mitogen activated protein kinase 1 | - |
dc.subject.keywordPlus | mitogen activated protein kinase p38 | - |
dc.subject.keywordPlus | mitogen activated protein kinase phosphatase 1 | - |
dc.subject.keywordPlus | proline | - |
dc.subject.keywordPlus | protein p53 | - |
dc.subject.keywordPlus | reactive oxygen metabolite | - |
dc.subject.keywordPlus | stress activated protein kinase | - |
dc.subject.keywordPlus | synaptophysin | - |
dc.subject.keywordPlus | transcription factor AP 1 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | cell proliferation | - |
dc.subject.keywordPlus | cellular distribution | - |
dc.subject.keywordPlus | DNA methylation | - |
dc.subject.keywordPlus | enzyme specificity | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | glycosylation | - |
dc.subject.keywordPlus | homeostasis | - |
dc.subject.keywordPlus | neuroprotection | - |
dc.subject.keywordPlus | phosphoproteomics | - |
dc.subject.keywordPlus | phosphorylation | - |
dc.subject.keywordPlus | protein dephosphorylation | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein interaction | - |
dc.subject.keywordPlus | protein methylation | - |
dc.subject.keywordPlus | protein phosphorylation | - |
dc.subject.keywordPlus | Review | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | upregulation | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scopus | - |
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