Molecular cloning of chicken interleukin-17B, which induces proinflammatory cytokines through activation of the NF-kappa B signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Hoang, Cong Thanh | - |
dc.contributor.author | Hong, Yeojin | - |
dc.contributor.author | Truong, Anh Duc | - |
dc.contributor.author | Lee, Janggeun | - |
dc.contributor.author | Lee, Kyungbaek | - |
dc.contributor.author | Hong, Yeong Ho | - |
dc.date.available | 2019-03-08T07:57:32Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 0145-305X | - |
dc.identifier.issn | 1879-0089 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3960 | - |
dc.description.abstract | Interleukin (IL)-17B is a little known member of the IL -17 cytokine family, which plays an important role in immunity by regulating the expression of proinflammatory cytokines. In this study, we determined the coding sequence and biological functions of a novel chicken IL-17B (chlL-17B). The full-length chIL-17B coding sequence includes 567 nucleotides encoding 188 amino acids, which was identified in small intestinal epithelial cells. The chIL-17B protein shares 96.48% amino acid sequence identity with turkey, 92.57% with duck, and 44.92-64.06% with mammalian IL-17B proteins. ChIL-17B shares three exons and two introns with mammals, turkey, and duck. Moreover, IL-17B mRNA was more highly expressed than IL-17A mRNA in several organs of chickens infected with Salmonella and was upregulated in chicken cell lines following LPS stimulation. In addition, in chicken cell lines, chlL-17B induced the mRNA expression of several proinflammatory cytokines, including IL-1 beta, IL-6, LITAF, and INF-gamma, but not IL-17A, and activated MyD88, TAK1, NF-031, and SOCS1, which are associated with the NF-kappa B signaling pathway. Taken together, chicken interleukin-17B plays a critical role in host defense against the bacterial pathogens, and regulates proinflammatory cytokines by activating the NF-kappa B signaling pathway. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Molecular cloning of chicken interleukin-17B, which induces proinflammatory cytokines through activation of the NF-kappa B signaling pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.dci.2017.04.010 | - |
dc.identifier.bibliographicCitation | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, v.74, pp 40 - 48 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000403512600006 | - |
dc.identifier.scopusid | 2-s2.0-85017602198 | - |
dc.citation.endPage | 48 | - |
dc.citation.startPage | 40 | - |
dc.citation.title | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | - |
dc.citation.volume | 74 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Chicken | - |
dc.subject.keywordAuthor | IL-17B | - |
dc.subject.keywordAuthor | NF-KB | - |
dc.subject.keywordAuthor | Signal transduction | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordPlus | FAMILY CYTOKINES | - |
dc.subject.keywordPlus | IL-17 FAMILY | - |
dc.subject.keywordPlus | IKK-ALPHA | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CONTRIBUTE | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.relation.journalResearchArea | Fisheries | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Fisheries | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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