돼지 로타바이러스(Gottfried 주)의 VP4 항원구조분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송윤경 | - |
dc.contributor.author | 김원용 | - |
dc.contributor.author | 강신영 | - |
dc.date.available | 2020-05-21T07:21:41Z | - |
dc.date.issued | 2001-09 | - |
dc.identifier.issn | 2466-1384 | - |
dc.identifier.issn | 2466-1392 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/39810 | - |
dc.description.abstract | The neutralization epitopes of the outer capsid protein VP4 of a porcine rotavirus, Gottfried strain, were studied using neutralizing monocolonal antibodies(N-MAbs). Eight N-MAbs which are specific for the VP4 of Gottfried strain were used for analyzing the antigenic sites of VP4. Three different approaches were used for this analysis; i)testing the serological reactivity of each N-MAb against different G and P types of human and animal rotavirusese ii) analyzing N-MAb-resistant viral escape mutants and iii) performing nucleotide sequence analysis of the VP4 gene of each N-MAb-resistant viral escape mutant. From experimental results, at least four antigenic sites(I, II, III, and IV) were identified. Antigenic site I recognized by N-MAbs 24B9, 23G10, and 26A2 was separated from antigenic site II recognized by N-MAbs 30H5, 32B3, and 29B3. However, these antigenic sites were overlapped with antigenic site III recognized by N-MAb 21A1. The other antigenic site IV recognized by N-MAb 16D2 was separated from antigenic sites I, II, and III. | - |
dc.format.extent | 8 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한수의학회 | - |
dc.title | 돼지 로타바이러스(Gottfried 주)의 VP4 항원구조분석 | - |
dc.title.alternative | Analysis of antigenic sites on the VP4 of porcine rotavirus, Gottfried strain | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한수의학회지, v.41, no.3, pp 343 - 350 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 350 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 343 | - |
dc.citation.title | 대한수의학회지 | - |
dc.citation.volume | 41 | - |
dc.identifier.url | https://www.koreascience.or.kr/article/JAKO200124457068059.page | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Rotavirus | - |
dc.subject.keywordAuthor | VP4 | - |
dc.subject.keywordAuthor | antigenic site | - |
dc.subject.keywordAuthor | N-MAb resistant escape mutant | - |
dc.subject.keywordAuthor | SSCP | - |
dc.description.journalRegisteredClass | kci | - |
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