3′-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models
DC Field | Value | Language |
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dc.contributor.author | Kang, Li-Jung | - |
dc.contributor.author | Oh, Eunjeong | - |
dc.contributor.author | Cho, Chanmi | - |
dc.contributor.author | Kwon, HoKeun | - |
dc.contributor.author | Lee, Choong-Gu | - |
dc.contributor.author | Jeon, Jimin | - |
dc.contributor.author | Lee, Hyemi | - |
dc.contributor.author | Choi,Sangil | - |
dc.contributor.author | Han, Seong Jae | - |
dc.contributor.author | Nam,Jiho | - |
dc.contributor.author | Song, Chi-une | - |
dc.contributor.author | Jung, Hyunho | - |
dc.contributor.author | Kim, Hye Young | - |
dc.contributor.author | Park, Eun-Jung | - |
dc.contributor.author | Choi, Eun-Ju | - |
dc.contributor.author | Kim, Jooyoung | - |
dc.contributor.author | Eyun, Seong-il | - |
dc.contributor.author | Yang, Si young | - |
dc.date.available | 2020-05-29T06:20:24Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/40073 | - |
dc.description.abstract | 3′-Sialyllactose (3′-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3′-SL on Treg regulation is unclear. This study aimed to investigate the effect of 3′-SL on Treg responses in atopic dermatitis (AD) pathogenesis. Oral administration of 3′-SL reduced AD-like symptoms such as ear, epidermal, and dermal thickness in repeated topical application of house dust mites (HDM) and 2,4-dinitrochlorobenzene (DNCB). 3′-SL inhibited IgE, IL-1β, IL-6, and TNF-α secretion and markedly downregulated AD-related cytokines including IL-4, IL-5, IL-6, IL-13, IL-17, IFN-γ, TNF-α, and Tslp through regulation of NF-κB in ear tissue. Additionally, in vitro assessment of Treg differentiation revealed that 3′-SL directly induced TGF-β-mediated Treg differentiation. Furthermore, 3′-SL administration also ameliorated sensitization and elicitation of AD pathogenesis by suppressing mast cell infiltration and production of IgE and pro-inflammatory cytokines in mouse serum by mediating the Treg response. Furthermore, Bifidobacterium population was also increased by 3′-SL administration as prebiotics. Our data collectively show that 3′-SL has therapeutic effects against AD progression by inducing Treg differentiation, downregulating AD-related cytokines, and increasing the Bifidobacterium population. © 2020, The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Research | - |
dc.title | 3′-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-020-62527-5 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.10, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000560407600008 | - |
dc.identifier.scopusid | 2-s2.0-85082472958 | - |
dc.citation.number | 1 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | THYMIC STROMAL LYMPHOPOIETIN | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | IGE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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