Characterization of Anti-Adhesion Properties of Alginate/Polyethylene Oxide Film to Reduce Postsurgical Peritoneal Adhesions
DC Field | Value | Language |
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dc.contributor.author | Kim, Duckil | - |
dc.contributor.author | Choi, Geun Joo | - |
dc.contributor.author | Baek, Seungho | - |
dc.contributor.author | Abdullah, Abdullah | - |
dc.contributor.author | Jang, Soohyun | - |
dc.contributor.author | Hong, Soon Auck | - |
dc.contributor.author | Kim, Beom Gyu | - |
dc.contributor.author | Lee, Joonhee | - |
dc.contributor.author | Kang, Hyun | - |
dc.contributor.author | Lee, Donghyun | - |
dc.date.available | 2019-03-08T07:58:12Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1947-2935 | - |
dc.identifier.issn | 1947-2943 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4028 | - |
dc.description.abstract | Postsurgical peritoneal adhesions lead to severe complications including chronic abdominal pain, female infertility, and small bowel obstruction. Adhesions can be minimized by introducing a physical barrier film between the tissues after surgery. We newly developed an anti-adhesive barrier film using alginate and polyethylene oxide (PEO). We determined the anti-adhesive properties of our alginate/PEO film through in vitro and in vivo studies. Alginate fibrous films were synthesized using electrospinning technique. PEO was added to alginate at 1:9 to minimize the repulsive forces within highly anionic alginate to make the fibrous film synthesis reproducible. The alginate/PEO film was then characterized for its morphology using atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy. For the in vitro study, NIH-3T3 cells were selected and cytotoxicity analysis was performed additionally. In the in vivo study, an intra-abdominal adhesion rat model was used. Sixty rats underwent laparotomy and cecal abrasion, and then, the alginate/PEO film was applied to the adhesion induction site. Peritoneal adhesion was assessed macroscopically and microscopically 2 weeks after surgery. In the in vitro study, alginate/PEO film exhibited enhanced anti-adhesive and cell repellent properties. In addition, the cytotoxicity analysis showed that the alginate/PEO film was non-toxic to mammalian cells. In the in vivo study, the alginate/PEO film showed significant adhesion reduction in both macroscopic and microscopic evaluations. The observed results suggest that the alginate/PEO film can be used as an effective physical barrier between tissues for reduced postsurgical peritoneal adhesions. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.title | Characterization of Anti-Adhesion Properties of Alginate/Polyethylene Oxide Film to Reduce Postsurgical Peritoneal Adhesions | - |
dc.type | Article | - |
dc.identifier.doi | 10.1166/sam.2017.3166 | - |
dc.identifier.bibliographicCitation | SCIENCE OF ADVANCED MATERIALS, v.9, no.9, pp 1669 - 1677 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000412929100036 | - |
dc.identifier.scopusid | 2-s2.0-85030834113 | - |
dc.citation.endPage | 1677 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1669 | - |
dc.citation.title | SCIENCE OF ADVANCED MATERIALS | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Alginate/Polyethylene Oxide Film | - |
dc.subject.keywordAuthor | Peritoneal Adhesion | - |
dc.subject.keywordAuthor | Anti-Adhesion | - |
dc.subject.keywordAuthor | NIH-3T3 | - |
dc.subject.keywordAuthor | Animal Model | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | ALGINATE | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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