Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model
DC Field | Value | Language |
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dc.contributor.author | Lee, Jae Yong | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Choi, Sung-Wook | - |
dc.contributor.author | Jeon, Daniel I. | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.date.available | 2019-03-08T07:58:33Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4065 | - |
dc.description.abstract | In this study, we evaluated in vitro osteogenic differentiation and in vivo new bone formation using the alendronate-releasing porous PLGA microsphere (Aln/PMS) system in rats with a critical-sized calvarial defect. Aln/PMS system significantly enhanced in vitro osteogenic differentiation and maturation, showing significantly enhanced ALP activity, calcium deposition and the expression of osteocalcin and osteopontin, relative to PMS alone. Also, micro-CT analyses and histology results suggested that Aln/PMS system increased mineralization and bone matrix formation compared to PMS alone. This study demonstrated that the local delivery of Aln, a potent-osteoinductive factor, significantly enhances rabbit adipose-derived stem cells osteogenesis and bone regeneration. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jiec.2017.03.057 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.52, pp 277 - 286 | - |
dc.identifier.kciid | ART002249852 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000402349800034 | - |
dc.identifier.scopusid | 2-s2.0-85017448641 | - |
dc.citation.endPage | 286 | - |
dc.citation.startPage | 277 | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 52 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Alendronate (Aln) | - |
dc.subject.keywordAuthor | Porous PLGA microspheres (PMSs) | - |
dc.subject.keywordAuthor | Rabbit adipose-derived stem cells (rADSCs) | - |
dc.subject.keywordAuthor | Calvarial defect model | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | OSTEOBLAST PROLIFERATION | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BEADS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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