Determination of the binding site of 2-aminothiazole derivative with importin beta 1 by UV-crosslinking experiment
DC Field | Value | Language |
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dc.contributor.author | Ha, Siyoung | - |
dc.contributor.author | Oh, Jiwon | - |
dc.contributor.author | Kim, Yong-Hak | - |
dc.contributor.author | Ham, Seung Wook | - |
dc.date.available | 2019-03-08T07:58:46Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1570-0232 | - |
dc.identifier.issn | 1873-376X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4085 | - |
dc.description.abstract | Importin beta 1 (KPBN1) appears to be overexpressed in several cancer cells and siRNA-induced inhibition of KPNB1 shows significant inhibition of cancer cell proliferation, but do not affect normal cells. These results indicate that KPNB1 is a potential target and inhibition of KPNB1 can be used as a novel therapeutic approach for the treatment of cancer. Recently, we identified the aminothiazole derivative 1 as a KPNB1-targeted anticancer agent. Herein, we report that compound 1 binds strongly to KPNB1, in a pocket centered around serine-476, as shown by UV-crosslinking and tandem mass spectrometry experiments, and supported using a model derived from molecular docking. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Determination of the binding site of 2-aminothiazole derivative with importin beta 1 by UV-crosslinking experiment | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jchromb.2017.05.037 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v.1060, pp 71 - 75 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000411540100010 | - |
dc.identifier.scopusid | 2-s2.0-85020270541 | - |
dc.citation.endPage | 75 | - |
dc.citation.startPage | 71 | - |
dc.citation.title | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | - |
dc.citation.volume | 1060 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordPlus | NUCLEAR-PROTEIN IMPORT | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | FRAGMENT | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | MITOSIS | - |
dc.subject.keywordPlus | CANCER | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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