Combination chemotherapy with irinotecan and cisplatin in elderly patients (≥65 years) with extensive-disease small-cell lung cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim H.-G. | - |
dc.contributor.author | Lee G.-W. | - |
dc.contributor.author | Kang J.H. | - |
dc.contributor.author | Kang M.-H. | - |
dc.contributor.author | Hwang I.-G. | - |
dc.contributor.author | Kim S.H. | - |
dc.contributor.author | Hahm J.R. | - |
dc.contributor.author | Jeong Y.Y. | - |
dc.contributor.author | Kim H.-C. | - |
dc.contributor.author | Lee J.D. | - |
dc.contributor.author | Lee J.-S. | - |
dc.contributor.author | Hwang Y.S. | - |
dc.date.available | 2020-06-26T08:20:11Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.issn | 1872-8332 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/41176 | - |
dc.description.abstract | Introduction: Combination chemotherapy with irinotecan and cisplatin is one of the standard treatments for patients with small-cell lung cancer (SCLC). In elderly patients, however, its efficacy and toxicity has not been well documented. In this Phase II study, we assessed the efficacy and toxicity of combination chemotherapy with irinotecan and cisplatin and examined whether advanced age compromises it in elderly patients with previously untreated extensive-disease small-cell lung cancer (ED-SCLC). Methods: In this study, 46 previously untreated elderly patients (65 years or older) with ED-SCLC were given combination chemotherapy consisting of irinotecan 60 mg/m2 on days 1, 8 and 15 and cisplatin 60 mg/m2 on day 1. The treatment was repeated every 4 weeks until patients completed the maximum six cycles. Results: Patients consisted of 37 men and 9 women, whose median age was 70 years (range 65-81 years). A complete response and a partial response were observed in 19.6% (9/46) and 56.5% (26/46), respectively. The overall response rate was 76.1% (95% C.I; 63.8-88.4%). The overall median survival was 10.4 months (range 7.6-13.2 months). The median progression-free survival was 8.32 months (range 6.8-9.8 months). Major toxicities included neutropenia (grade 3-4, 58.7%), leukopenia (grade 3-4, 49.9%), infection (grade 3-4, 39.1%) and diarrhea (grade 3-4, 30.4%). Incidence of febrile neutropenia was significantly higher in patients with ECOG performance status 2-3 compared with ECOG performance status 0-1 (70.4% vs. 5.2%; p < 0.001). There were two treatment related deaths in patients ECOG performance status 3. Conclusions: Our results indicate that combination chemotherapy with irinotecan and cisplatin is an effective treatment for elderly patients with ED-SCLC who have good ECOG performance status and physicians should be aware of the mortality and morbidity due to myelosuppression following this treatment in elderly ED-SCLC patients with poor ECOG performance status. © 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Combination chemotherapy with irinotecan and cisplatin in elderly patients (≥65 years) with extensive-disease small-cell lung cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.lungcan.2007.12.020 | - |
dc.identifier.bibliographicCitation | Lung Cancer, v.61, no.2, pp 220 - 226 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000259288700011 | - |
dc.identifier.scopusid | 2-s2.0-47649114357 | - |
dc.citation.endPage | 226 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 220 | - |
dc.citation.title | Lung Cancer | - |
dc.citation.volume | 61 | - |
dc.type.docType | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.subject.keywordAuthor | Cisplatin | - |
dc.subject.keywordAuthor | Elderly | - |
dc.subject.keywordAuthor | Irinotecan | - |
dc.subject.keywordAuthor | Small-cell lung cancer | - |
dc.subject.keywordPlus | cisplatin | - |
dc.subject.keywordPlus | irinotecan | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | anemia | - |
dc.subject.keywordPlus | anorexia | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cancer survival | - |
dc.subject.keywordPlus | clinical trial | - |
dc.subject.keywordPlus | combination chemotherapy | - |
dc.subject.keywordPlus | constipation | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diarrhea | - |
dc.subject.keywordPlus | drug dose reduction | - |
dc.subject.keywordPlus | drug efficacy | - |
dc.subject.keywordPlus | drug safety | - |
dc.subject.keywordPlus | drug withdrawal | - |
dc.subject.keywordPlus | dyspnea | - |
dc.subject.keywordPlus | elderly care | - |
dc.subject.keywordPlus | esophagitis | - |
dc.subject.keywordPlus | febrile neutropenia | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | infection | - |
dc.subject.keywordPlus | leukopenia | - |
dc.subject.keywordPlus | lung small cell cancer | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mucosa inflammation | - |
dc.subject.keywordPlus | multiple cycle treatment | - |
dc.subject.keywordPlus | nausea and vomiting | - |
dc.subject.keywordPlus | neutropenia | - |
dc.subject.keywordPlus | phase 2 clinical trial | - |
dc.subject.keywordPlus | pneumonia | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | thrombocytopenia | - |
dc.subject.keywordPlus | treatment response | - |
dc.subject.keywordPlus | Age Factors | - |
dc.subject.keywordPlus | Aged | - |
dc.subject.keywordPlus | Aged, 80 and over | - |
dc.subject.keywordPlus | Antineoplastic Combined Chemotherapy Protocols | - |
dc.subject.keywordPlus | Camptothecin | - |
dc.subject.keywordPlus | Carcinoma, Small Cell | - |
dc.subject.keywordPlus | Cisplatin | - |
dc.subject.keywordPlus | Disease-Free Survival | - |
dc.subject.keywordPlus | Drug Toxicity | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Lung Neoplasms | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Neoplasm Staging | - |
dc.subject.keywordPlus | Neutropenia | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.