The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma
DC Field | Value | Language |
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dc.contributor.author | Park, Sarah | - |
dc.contributor.author | Lee, Jeeyun | - |
dc.contributor.author | Ko, Young Hyeh | - |
dc.contributor.author | Han, Arum | - |
dc.contributor.author | Jun, Hyun Jung | - |
dc.contributor.author | Lee, Sang Chul | - |
dc.contributor.author | Hwang, In Gyu | - |
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Ahn, Jin Seok | - |
dc.contributor.author | Jung, Chul Won | - |
dc.contributor.author | Kim, Kihyun | - |
dc.contributor.author | Ahn, Yong Chan | - |
dc.contributor.author | Kang, Won Ki | - |
dc.contributor.author | Park, Keunchil | - |
dc.contributor.author | Kim, Won Seog | - |
dc.date.available | 2020-07-01T05:20:21Z | - |
dc.date.issued | 2007-08 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.issn | 1528-0020 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/41334 | - |
dc.description.abstract | To define prognostic impact of Epstein-Barr virus (EBV) infection in diffuse large B-cell lymphoma (DLBCL), we investigated EBV status in patients with DLBCL. In all, 380 slides from paraffin-embedded tissue were available for analysis by EBV-encoded RNA-1 (EBER) in situ hybridization, and 34 cases (9.0%) were identified as EBER-positive. EBER positivity was significantly associated with age greater than 60 years (P = .005), more advanced stage (P <= .001), more than one extranodal involvement (P = .009), higher International Prognostic Index (IPI) risk group (P = .015), presence of B symptom (P = .004), and poorer outcome to initial treatment (P = .006). The EBER+ patients with DLBCL demonstrated substantially poorer overall survival (EBER+ vs EBER(-)35.8 months [95% confidence interval (0), 0-114.1 months] vs not reached, P = .026) and progression-free survival (EBER+ vs EBER- 12.8 months [95% CI, 0-31.8 months] vs 35.8 months [95% CI, 0-114.1 months], respectively (P=.018). In nongerminal center B-cell-like subtype, EBER in situ hybridization positivity retained its statistical significance at the multivariate level (P = .045). Nongerminal center B-cell-like patients with DLBCL with EBER positivity showed substantially poorer overall survival with 2.9-fold (95% CI, 1.1-8.1) risk for death. Taken together, DLBCL patients with EBER in situ hybridization(+) pursued more rapidly deteriorating clinical course with poorer treatment response, survival, and progression-free survival. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC HEMATOLOGY | - |
dc.title | The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1182/blood-2007-01-067769 | - |
dc.identifier.bibliographicCitation | BLOOD, v.110, no.3, pp 972 - 978 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000248514700034 | - |
dc.citation.endPage | 978 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 972 | - |
dc.citation.title | BLOOD | - |
dc.citation.volume | 110 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | LATENT MEMBRANE PROTEIN-1 | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELL | - |
dc.subject.keywordPlus | IMMUNOCOMPETENT PATIENTS | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordPlus | EBV | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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