Anti-inflammatory effects of Nelumbo leaf extracts and identification of their metabolites
DC Field | Value | Language |
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dc.contributor.author | Park, Eunkyo | - |
dc.contributor.author | Kim, Gyoung Deuck | - |
dc.contributor.author | Go, Min-Sun | - |
dc.contributor.author | Kwon, Dodan | - |
dc.contributor.author | Jung, In-Kyung | - |
dc.contributor.author | Auh, Joong Hyuck | - |
dc.contributor.author | Kim, Jung-Hyun | - |
dc.date.available | 2019-03-08T08:36:27Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.issn | 2005-6168 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4161 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: Nelumbo leaves have been used in traditional medicine to treat bleeding, gastritis, hemorrhoids, and halitosis. However, their mechanisms have not been elucidated. MATERIALS/METHODS: The present study prepared two Nelumbo leaf extracts (NLEs) using water or 50% ethanol. Inflammatory response was induced with LPS treatment, and expression of pro-inflammatory mediators (inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha (TNF-alpha), interleukin (1L)-1 beta, and IL-6 and nitric oxide (NO) and prostaglandin E-2 (PGE(2)) productions were assessed. To determine the anti-inflammatory mechanism of NLEs, we measured nuclear factor-kappa B (NF-kappa B) activity. Major metabolites of NLEs were also analyzed and quantified. RESULTS: NLEs effectively reduced the expression and productions of pro-inflammatory mediators such as IL-1 beta, IL-6, TNF-alpha, PGE(2), and NO. NLEs also reduced NF-kappa B activity by inhibiting inhibitor of NF-kappa B phosphorylation. Both extracts contained catechin and quercetin, bioactive compounds of NLEs. CONCLUSIONS: In this study, we showed that NLEs could be used to inhibit NF-kappa B-mediated inflammatory responses. In addition, our data support the idea that NLEs can ameliorate disease conditions involving chronic inflammation. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.title | Anti-inflammatory effects of Nelumbo leaf extracts and identification of their metabolites | - |
dc.type | Article | - |
dc.identifier.doi | 10.4162/nrp.2017.11.4.265 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.11, no.4, pp 265 - 274 | - |
dc.identifier.kciid | ART002248348 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000407539600001 | - |
dc.identifier.scopusid | 2-s2.0-85026795893 | - |
dc.citation.endPage | 274 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 265 | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Nelumbo leaf | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | metabolomics | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NUCIFERA LEAVES | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | (+)-CATECHIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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