Simple microwire and microcatheter mechanical thrombolysis with adjuvant intraarterial urokinase for treatment of hyperacute ischemic stroke patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Dong Joon | - |
dc.contributor.author | Kim, Dong Ik | - |
dc.contributor.author | Byun, Jun Su | - |
dc.contributor.author | Jung, Jin Young | - |
dc.contributor.author | Suh, Sang Hyun | - |
dc.contributor.author | Kim, Eung Yeop | - |
dc.contributor.author | Lee, Kyung-Yul | - |
dc.contributor.author | Heo, Ji Hoe | - |
dc.date.available | 2020-07-16T03:23:36Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0284-1851 | - |
dc.identifier.issn | 1600-0455 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/41974 | - |
dc.description.abstract | Background: Mechanical thrombolysis may effectively enhance the efficacy of thrombolysis for hyperacute ischemic stroke patients. Purpose: To assess the feasibility and results of simple mechanical-based thrombolysis using microwire and microcatheter with adjuvant low-dose intraarterial (i.a.) urokinase (UK) for the treatment of hyperacute ischemic stroke. Material and Methods: Nineteen consecutive patients with hyperacute proximal middle cerebral artery (MCA) occlusions treated by a standardized protocol using microwire and microcatheter for mechanical thrombus disruption with adjuvant i.a. UK were reviewed. Simple to-and-fro passages through the clot with the microwire and microcatheter followed by disruptions by a J- or pigtail-shaped wire tip with alternating small-dose injections of UK distal, within, and proximal to the clot were performed. The recanalization rates, post-thrombolysis hemorrhage, and clinical outcome (baseline and discharge National Institute of Health Stroke Scale [NIHSS], mortality, 3-month modified Rankin scale [mRS]) were evaluated. Results: Recanalization was achieved in 18 of 19 patients (94.7%). The mean UK dose was 375,789 IU (range 130,000-580,000 IU). Two patients (10.5%) developed symptomatic hemorrhage. One of the hemorrhages included a patient who developed subarachnoid hemorrhage. Mortality rate was 15.8% (n=3). The median baseline NIHSS scores showed improvement from 17 to 10 at presentation and discharge, respectively. At three months, good outcome was noted in 11 of 19 patients (57.9%, mRS 0-2). Conclusion: Simple mechanical-based thrombolysis using microwire and microcatheter with adjuvant low-dose i.a. UK is safe and effective in achieving recanalization with good long-term outcome. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.title | Simple microwire and microcatheter mechanical thrombolysis with adjuvant intraarterial urokinase for treatment of hyperacute ischemic stroke patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/02841850701819143 | - |
dc.identifier.bibliographicCitation | ACTA RADIOLOGICA, v.49, no.3, pp 351 - 357 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000254346400020 | - |
dc.citation.endPage | 357 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 351 | - |
dc.citation.title | ACTA RADIOLOGICA | - |
dc.citation.volume | 49 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | CNS | - |
dc.subject.keywordAuthor | interventional | - |
dc.subject.keywordAuthor | ischemia/infarction | - |
dc.subject.keywordAuthor | thrombolysis | - |
dc.subject.keywordPlus | TISSUE-PLASMINOGEN-ACTIVATOR | - |
dc.subject.keywordPlus | PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | CLOT DISRUPTION | - |
dc.subject.keywordPlus | SEQUENTIAL COMBINATION | - |
dc.subject.keywordPlus | EMBOLUS REMOVAL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | RECANALIZATION | - |
dc.subject.keywordPlus | PROUROKINASE | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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