Nonclassical Kinetics of Clonal yet Heterogeneous Enzymes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seong Jun | - |
dc.contributor.author | Song, Sanggeun | - |
dc.contributor.author | Jeong, In-Chun | - |
dc.contributor.author | Koh, Hye Ran | - |
dc.contributor.author | Kim, Ji-Hyun | - |
dc.contributor.author | Sung, Jaeyoung | - |
dc.date.available | 2019-03-08T08:37:01Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1948-7185 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4224 | - |
dc.description.abstract | Enzyme-to-enzyme variation in the catalytic rate is ubiquitous among single enzymes created from the same genetic information, which persists over the lifetimes of living cells. Despite advances in single-enzyme technologies, the lack of an enzyme reaction model accounting for the heterogeneous activity of single enzymes has hindered a quantitative understanding of the nonclassical stochastic outcome of single enzyme systems. Here we present a new statistical kinetics and exactly solvable models for clonal yet heterogeneous enzymes with possibly nonergodic state dynamics and state-dependent reactivity, which enable a quantitative understanding of modern single-enzyme experimental results for the mean and fluctuation in the number of product molecules created by single enzymes. We also propose a new experimental measure of the heterogeneity and nonergodicity for a system of enzymes. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Nonclassical Kinetics of Clonal yet Heterogeneous Enzymes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jpclett.7b01218 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHYSICAL CHEMISTRY LETTERS, v.8, no.13, pp 3152 - 3158 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000405252600059 | - |
dc.identifier.scopusid | 2-s2.0-85021888665 | - |
dc.citation.endPage | 3158 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 3152 | - |
dc.citation.title | JOURNAL OF PHYSICAL CHEMISTRY LETTERS | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | MICHAELIS-MENTEN EQUATION | - |
dc.subject.keywordPlus | SINGLE | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | HELICASE | - |
dc.subject.keywordPlus | NOISE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Atomic, Molecular & Chemical | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.