Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice
DC Field | Value | Language |
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dc.contributor.author | Dang, Duy-Khanh | - |
dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Mai, Anh-Thu | - |
dc.contributor.author | Jang, Choon-Gon | - |
dc.contributor.author | Nah, Seung-Yeol | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Ledent, Catherine | - |
dc.contributor.author | Yamamoto, Tsuneyuki | - |
dc.contributor.author | Nabeshima, Toshitaka | - |
dc.contributor.author | Onaivi, Emmanuel S. | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.date.available | 2019-03-08T08:37:16Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.issn | 1873-4596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4249 | - |
dc.description.abstract | Accumulating evidence suggests that cannabinoid ligands play delicate roles in cell survival and apoptosis decisions, and that cannabinoid CB1 receptors (CB1R) modulate dopaminergic function. However, the role of CB1R in methamphetamine (MA)-induced dopaminergic neurotoxicity in vivo remains elusive. Multiple high doses of MA increased phospho-ERK and CB1R mRNA expressions in the striatum of CB1R (+/+) mice. These increases were attenuated by CB1R antagonists (i.e., AM251 and rimonabant), an ERK inhibitor (U0126), or dopamine D2R antagonist (sulpiride). In addition, treatment with MA resulted in dopaminergic impairments, which were attenuated by CB1R knockout or CB1R antagonists (i.e., AM251 and rimonabant). Consistently, MA-induced oxidative stresses (i.e., protein oxidation, lipid peroxidation and reactive oxygen species) and proapoptotic changes (i.e., increases in Bax, cleaved PKCd-and cleaved caspase 3-expression and decrease in Bcl-2 expression) were observed in the striatum of CB1R (+/+) mice. These toxic effects were attenuated by CB1R knockout or CB1R antagonists. Consistently, treatment with four high doses of CB1R agonists (i. e., WIN 55,212-2 36 mg/kg and ACEA 16 mg/kg) also resulted in significant oxidative stresses, pro-apoptotic changes, and dopaminergic impairments. Since CB1R co-immunoprecipitates PKCd in the presence of MA or CB1R agonists, we applied PKCd knockout mice to clarify the role of PKCd in the neurotoxicity elicited by CB1Rs. CB1R agonist-induced toxic effects were significantly attenuated by CB1R knockout, CB1R antagonists or PKCd knockout. Therefore, our results suggest that interaction between D2R, ERK and CB1R is critical for MA-induced dopaminergic neurotoxicity and that PKCd mediates dopaminergic damage induced by high-doses of CB1R agonist. | - |
dc.format.extent | 21 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2017.03.033 | - |
dc.identifier.bibliographicCitation | FREE RADICAL BIOLOGY AND MEDICINE, v.108, pp 204 - 224 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000403463500020 | - |
dc.identifier.scopusid | 2-s2.0-85016736825 | - |
dc.citation.endPage | 224 | - |
dc.citation.startPage | 204 | - |
dc.citation.title | FREE RADICAL BIOLOGY AND MEDICINE | - |
dc.citation.volume | 108 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Methamphetamine | - |
dc.subject.keywordAuthor | Dopaminergic and behavioral impairments | - |
dc.subject.keywordAuthor | Striatum | - |
dc.subject.keywordAuthor | Dopamine D2 receptor | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | cannabinoid CB1 receptor | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | PKCd | - |
dc.subject.keywordPlus | KINASE-C-DELTA | - |
dc.subject.keywordPlus | CULTURED CORTICAL-NEURONS | - |
dc.subject.keywordPlus | MESSENGER-RNA LEVELS | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BEHAVIORAL SENSITIZATION | - |
dc.subject.keywordPlus | ENDOCANNABINOID SYSTEM | - |
dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
dc.subject.keywordPlus | INDUCED HYPERTHERMIA | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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