Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth
DC Field | Value | Language |
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dc.contributor.author | Oh H.A. | - |
dc.contributor.author | Kwak J. | - |
dc.contributor.author | Kim B.J. | - |
dc.contributor.author | Jin H.J. | - |
dc.contributor.author | Park W.S. | - |
dc.contributor.author | Choi S.J. | - |
dc.contributor.author | Oh W. | - |
dc.contributor.author | Um S. | - |
dc.date.available | 2020-08-03T06:25:56Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/42731 | - |
dc.description.abstract | Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-β1 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). P-CM significantly increased the viability of DPCs compared to CM. The secretion of vascular endothelial growth factor (VEGF) in DPCs was regulated by the macrophage migration inhibitory factor (MIF) in the P-CM secreted by MSCs. These findings suggest that P-CM can improve the efficacy in hair growth via a paracrine mechanism and that MIF in P-CM exerts hair growth-promoting effects via a VEGF-related β-catenin and p-GSK-3β [SER9] signaling pathway. Furthermore, clinical trials have shown that 5% P-CM improved androgenetic alopecia through producing an increased hair density, thickness, and growth rate, suggesting that this topical agent may be a novel and effective treatment option for patients with androgenetic alopecia. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/cells9061344 | - |
dc.identifier.bibliographicCitation | Cells, v.9, no.6 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000550727000001 | - |
dc.identifier.scopusid | 2-s2.0-85085676490 | - |
dc.citation.number | 6 | - |
dc.citation.title | Cells | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | androgenic alopecia | - |
dc.subject.keywordAuthor | conditioned media | - |
dc.subject.keywordAuthor | hair growth | - |
dc.subject.keywordAuthor | human mesenchymal stromal cells | - |
dc.subject.keywordAuthor | MIF | - |
dc.subject.keywordAuthor | VEGF | - |
dc.subject.keywordPlus | DERMAL PAPILLA CELLS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | WNT/BETA-CATENIN | - |
dc.subject.keywordPlus | FACTOR MIF | - |
dc.subject.keywordPlus | ALOPECIA | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ANDROGEN | - |
dc.subject.keywordPlus | TGF-BETA-1 | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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