TLR2 contributes to trigger immune response of pleural mesothelial cells against Mycobacterium bovis BCG and M. tuberculosis infection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwanga, Eun-Ha | - |
dc.contributor.author | Kim, Tae-Hyoun | - |
dc.contributor.author | Park, Ji-Yeon | - |
dc.contributor.author | Hong, Jung Joo | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Ha, Sang-Jun | - |
dc.contributor.author | Yang, Soo-Jin | - |
dc.contributor.author | Shin, Sung Jae | - |
dc.contributor.author | Park, Jong-Hwan | - |
dc.date.available | 2019-03-08T08:37:33Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.issn | 1096-0023 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4281 | - |
dc.description.abstract | Mycobacterium tuberculosis is a causative agent leading to pleural effusion, characterized by the accumulation of fluid and immune cells in the pleural cavity. Although this phenomenon has been described before, detailed processes or mechanisms associated with the pleural effusion are still not well understood. Pleural mesothelial cells (PMCs) are specialized epithelial cells that cover the body wall and internal organs in pleural cavity playing a central role in pleural inflammation. Toll-like receptors are expressed in various cell types including mesothelial cells and initiate the recognition and defense against mycobacterial infection. In the present study, we investigated direct immune responses of PMCs against two mycobacterial strains, M. bovis vaccine strain Bacille Calmette-Guerin (BCG) and M. tuberculosis virulent strain H37Rv, and the role of TLR2 in such responses. Infection with BCG and H37Rv increased the production of IL-6, CXCL1, and CCL2 in WT PMCs, which was partially impaired in TLR2-deficient cells. In addition, the activation of NF-kappa B and MAPKs induced by BCG and H37Rv was suppressed in TLR2-deficient PMCs, as compared with the WT cells. TLR2 deficiency led to the decrease of nitric oxide (NO) production through the delayed gene expression of iNOS in PMCs. TLR2 was also shown to be essential for optimal expression of cellular adhesion molecules such as ICAM-1 and VCAM-1 in PMCs in response to BCG and H37Rv. These findings strongly suggest that TLR2 participates in mycobacteria-induced innate immune responses in PMCs and may play a role in pathogenesis of tuberculosis pleural effusion. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.title | TLR2 contributes to trigger immune response of pleural mesothelial cells against Mycobacterium bovis BCG and M. tuberculosis infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cyto.2017.02.021 | - |
dc.identifier.bibliographicCitation | CYTOKINE, v.95, pp 80 - 87 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000405054600012 | - |
dc.identifier.scopusid | 2-s2.0-85013861623 | - |
dc.citation.endPage | 87 | - |
dc.citation.startPage | 80 | - |
dc.citation.title | CYTOKINE | - |
dc.citation.volume | 95 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Mycobacterium tuberculosis | - |
dc.subject.keywordAuthor | Pleural mesothelial cells | - |
dc.subject.keywordAuthor | TLR2 | - |
dc.subject.keywordAuthor | Innate immune response | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | CHEMOKINE EXPRESSION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | EFFUSION | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | PEPTIDOGLYCAN | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.