Enhancing Lysozyme Loading in Powderized Liposomes by Controlling Encapsulation Processes
DC Field | Value | Language |
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dc.contributor.author | Ro, Jieun | - |
dc.contributor.author | Park, Changhee | - |
dc.contributor.author | Kim, Jeong Tae | - |
dc.contributor.author | Kim, Hyeongmin | - |
dc.contributor.author | Lee, Young-Eun | - |
dc.contributor.author | Yoo, Seung-Yup | - |
dc.contributor.author | Hong, Seong-Chul | - |
dc.contributor.author | Lee, Kyung Bin | - |
dc.contributor.author | Lee, Jaehwi | - |
dc.date.available | 2019-03-08T08:37:38Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4287 | - |
dc.description.abstract | Liposomes have demonstrated great potentials as protein carriers in various pharmaceutical applications. However, low loading amount of proteins in liposomes have been a major challenge for maximizing the therapeutics potential of the proteins. We thus aimed to enhance the loading amount of a model protein, lysozyme, in liposomes by controlling key experimental variables of a reverse phase evaporation method. The loading amount of lysozyme in liposomes was evaluated with changing type of organic solvents used, weight ratio of lysozyme/phosphatidylcholine, and volume ratio of aqueous to organic phase along with particle characterization before and after freeze-drying procedure. As a result, the loading amount of lysozyme in liposomes was considerably enhanced and the physical stability of the liposomes was maintained without any significant changes in the particle characteristics for 7 days. The findings of this study would be useful for highly efficient loading of protein therapeutics in liposomes, leading to improved therapeutic effects of the drugs. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Enhancing Lysozyme Loading in Powderized Liposomes by Controlling Encapsulation Processes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bkcs.11164 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.38, no.7, pp 744 - 750 | - |
dc.identifier.kciid | ART002245421 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000405452400010 | - |
dc.identifier.scopusid | 2-s2.0-85020217456 | - |
dc.citation.endPage | 750 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 744 | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 38 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Lysozyme | - |
dc.subject.keywordAuthor | Liposome | - |
dc.subject.keywordAuthor | Encapsulation | - |
dc.subject.keywordAuthor | Reverse phase evaporation method | - |
dc.subject.keywordAuthor | Protein therapeutics | - |
dc.subject.keywordPlus | REVERSE-PHASE EVAPORATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | STABILIZATION | - |
dc.subject.keywordPlus | CONFORMATION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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