The Utility of the Random Urine Uric Acid-to-Creatinine Ratio for Patients with Gout Who Need Uricosuric Agents: Retrospective Cross-Sectional StudyThe Utility of the Random Urine Uric Acid-to-Creatinine Ratio for Patients with Gout Who Need Uricosuric Agents: Retrospective Cross-Sectional Study
- Authors
- Choi, Sang Tae; Song, Jung Soo; Kim, Seung Jun; Kim, Chan Ho; Moon, Sung Jin
- Issue Date
- Apr-2020
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Urine; Uric Acid; Creatinine; Gout; Uricosuric Agents
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.35, no.13, pp 1 - 8
- Pages
- 8
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 35
- Number
- 13
- Start Page
- 1
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/42889
- DOI
- 10.3346/jkms.2020.35.e95
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: The 24-hour uric acid excretion measurement is important in assessing disease status and helping to select the appropriate uric acid-lowering agent for patients with gout, however, it is inconvenient. The authors investigated the efficacy of the random urine uric acidto-creatinine (UA/CR) ratio to screen the patients who under-secreted 24-hour urine uric acid. Methods: This was a retrospective cross-sectional study. Ninety patients with gout, without undergoing uric acid-lowering treatment were enrolled. Twenty-four-hour urine and random urine samples were obtained on the same day. Six hundred mg of uric acid in the 24-hour urine sample was used as a standard for distinguishing between over and under-excretion groups. Results: The random urinary UA/CR ratio showed positive correlation with 24-hour urine uric acid excretion (gamma = 0.398, P< 0.001). All the patients with the random UA/CR less than 0.2 excreted less than 600 mg uric acid in 24-hour urine collection. When the random urine UA/CR ratio < 0.2 was regarded as a positive result, the positive predictive value, negative predictive value, sensitivity, and specificity in the uric acid under-excretion were 100% (8 of 8), 64.6% (53 of 82), 21.6% (8 of 37), and 100% (53 of 53), respectively. Conclusion: There is a moderate positive correlation between the random urinary UA/CR ratio and 24-hour urine uric acid excretion, so that UA/CR ratio may not be a good predictor of 24-hour urine uric acid excretion. However, the random urine UA/CR ratio 0.2 can be a useful predictor to screen the gouty patients who need to be treated with uricosuric drugs.
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