Pattern-Coated Titanium Bone Fixation Plate for Dual Delivery of Vancomycin and Alendronate
- Authors
- Park, Chun Gwon; Park, Min; Kim, Byung Hwi; Lee, Seung Ho; Park, Joong Yull; Park, Ho Hyun; Lee, Kangwon; Seok, Hyun-Kwang; Choy, Young Bin
- Issue Date
- Jul-2017
- Publisher
- SPRINGER
- Keywords
- alendronate; bone plate; drug delivery; surface coating; vancomycin
- Citation
- MACROMOLECULAR RESEARCH, v.25, no.7, pp 756 - 762
- Pages
- 7
- Journal Title
- MACROMOLECULAR RESEARCH
- Volume
- 25
- Number
- 7
- Start Page
- 756
- End Page
- 762
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4294
- DOI
- 10.1007/s13233-017-5073-1
- ISSN
- 1598-5032
2092-7673
- Abstract
- Metallic bone-fixation devices have been widely used in the treatment of fractured bones. However, there are still some unmet clinical needs associated with post-surgical infection and hampered bone repair. Therefore, to both prevent infection and enhance bone formation, we propose a titanium (Ti)-based bone plate for dual delivery of an antibiotic, vancomycin (VAN), and a bone-forming drug, alendronate (AL). In this work, we prepared the coating with a blend of a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), and a drug, VAN or AL. Instead of coating the whole surface, we patterned the coatings each in the shape of a dot, on a flat surface of the Ti bone plate currently in clinical use (BP0001-PT, U&I, Korea). This way, we could prevent detachment of the polymeric coating from the metallic plate surface while being immersed in an aqueous medium for 23 days. Both VAN and AL were released in a sustained manner for more than 28 days, maintaining their own activity without being influenced by their co-existence in the medium. Thus, the coated plate showed an antibacterial activity against Staphylococcus aureus, while also promoting osteoblast proliferation and alkaline phosphate activity in MG-63 cells. Therefore, we conclude that a Ti-based bone plate coated with patterned dots, each for delivery of VAN or AL, can be a promising strategy to allow for both antibacterial and bone-forming activities.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > School of Mechanical Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4294)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.