Effect of dietary bioactive compounds and biopolymer encapsulated lipids on metabolism of lipids in high fat diet-fed mice

Abstract

Wedeterminedthe effects of dietarybioactivecomponentsandbiopolymer encapsulationonlipids'metabolism in obesemice. Six randomgroups of 60 obese mice were fed the following diets for 95 days: Basal diet; cellulose encapsulated lipids; pectinandchitosanencapsulatedlipids(EPC); Camellia sinensisandCoix lacrymaenhanced diet; C. sinensisandC. lacrymadiet plus pectin andchitosan encapsulated lipids; hydroxycitric acid, caffeine, and vitamin C enhanced diet plus pectin and chitosan encapsulated lipids (HCVEPC). The HCVEPC groupusually presented lower body and to taladipose tissueweight comparedtootherdiet groups. Intestine lengthwas not significantly different among all dietary groups. Serum leptin, triglycerides, and cholesterol were significantly lower in EPC and HCVEPC compared to other groups. However, serum glucose was not significantly different among groups. Our results indicate that bioactive compounds and biopolymers' encapsulation act synergistically in the reduction of body and adipose tissue weight.