Biphasic Calcium Phosphate (BCP)-Immobilized Porous Poly (D,L-Lactic-co-Glycolic Acid) Microspheres Enhance Osteogenic Activities of Osteoblasts
DC Field | Value | Language |
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dc.contributor.author | Shim, Kyu-Sik | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Choi, Somang | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.date.available | 2019-03-08T08:37:49Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4309 | - |
dc.description.abstract | The purpose of this study was to evaluate the potential of porous poly (D, L-lactic-co-glycolic acid) (PLGA) microspheres (PMSs) immobilized on biphasic calcium phosphate nanoparticles (BCP NPs) (BCP-IM-PMSs) to enhance osteogenic activity. PMSs were fabricated using a fluidic device, and their surfaces were modified with L-lysine (aminated-PMSs), whereas the BCP NPs were modified with heparin-dopamine (Hep-DOPA) to obtain heparinized-BCP (Hep-BCP) NPs. BCP-IM-PMSs were fabricated via electrostatic interactions between the Hep-BCP NPs and aminated-PMSs. The fabricated BCP-IM-PMSs showed an interconnected pore structure. In vitro studies showed that MG-63 cells cultured on BCP-IM-PMSs had increased alkaline phosphatase activity, calcium content, and mRNA expression of osteocalcin (OCN) and osteopontin (OPN) compared with cells cultured on PMSs. These data suggest that BCP NP-immobilized PMSs have the potential to enhance osteogenic activity. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Biphasic Calcium Phosphate (BCP)-Immobilized Porous Poly (D,L-Lactic-co-Glycolic Acid) Microspheres Enhance Osteogenic Activities of Osteoblasts | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/polym9070297 | - |
dc.identifier.bibliographicCitation | POLYMERS, v.9, no.7 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000407726900046 | - |
dc.identifier.scopusid | 2-s2.0-85025638090 | - |
dc.citation.number | 7 | - |
dc.citation.title | POLYMERS | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | porous microspheres (PMSs) | - |
dc.subject.keywordAuthor | biphasic calcium phosphate (BCP) | - |
dc.subject.keywordAuthor | MG-63 cells | - |
dc.subject.keywordAuthor | osteogenic activity | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | COMPOSITE SCAFFOLDS | - |
dc.subject.keywordPlus | BONE-FORMATION | - |
dc.subject.keywordPlus | PLGA MICROSPHERES | - |
dc.subject.keywordPlus | DEFECT MODEL | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | TITANIUM | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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