Oncologic and surgical outcomes in colorectal cancer patients with liver cirrhosis: A propensity-matched study
DC Field | Value | Language |
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dc.contributor.author | Han, Eon Chul | - |
dc.contributor.author | Ryoo, Seung-Bum | - |
dc.contributor.author | Park, Ji Won | - |
dc.contributor.author | Yi, Jin Wook | - |
dc.contributor.author | Oh, Heung-Kwon | - |
dc.contributor.author | Choe, Eun Kyung | - |
dc.contributor.author | Ha, Heon-Kyun | - |
dc.contributor.author | Park, Byung Kwan | - |
dc.contributor.author | Moon, Sang Hui | - |
dc.contributor.author | Jeong, Seung-Yong | - |
dc.contributor.author | Park, Kyu Joo | - |
dc.date.available | 2019-03-08T08:38:05Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4338 | - |
dc.description.abstract | The management of colorectal cancer in patients with liver cirrhosis requires a thorough understanding of both diseases. This study evaluated the effect of liver cirrhosis on oncologic and surgical outcomes and prognostic factors in colorectal cancer patients. Fifty-five consecutive colorectal cancer patients with liver cirrhosis underwent colorectal resection (LC group). Using a prospectively maintained database, these patients were matched 1: 4 using propensity scoring with R programming language, package "MatchIt" and "optmatch" by sex, age, cancer location, and tumor stage with 220 patients without liver cirrhosis (non-LC group), resulting in 275 patients. The 5-year overall survival (OS) was significantly worse in the LC group than in the non-LC group (46.7% vs. 76.2% respectively, P < 0.001); however, the 5-year proportion of recurrence free (PRF) rates were similar (73.1% vs. 84.5% respectively, P = 0.094). On multivariate analysis of the LC group, tumor-node-metastasis (TNM) stage >= III disease, venous invasion, and a model for end-stage liver disease plus serum sodium (MELD-Na) score >10 were prognostic factors for OS. However, the OS was not different between the LC group with MELD-Na score <= 10 and the non-LC group (5-year OS rate, TNM stage <= II, 85.7 vs 89.5%, p = 0.356; TNM stage >= III, 41.1 vs 66.2%, p = 0.061). Colorectal cancer patients with liver cirrhosis have poorer OS compared to those without liver cirrhosis; however, the PRF rates are similar. It might be due to the mortality from the liver, and surgical treatment should be actively considered for patients with MELD-Na score <10. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Oncologic and surgical outcomes in colorectal cancer patients with liver cirrhosis: A propensity-matched study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0178920 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.12, no.6 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000402875700036 | - |
dc.identifier.scopusid | 2-s2.0-85020216720 | - |
dc.citation.number | 6 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | RED-BLOOD-CELLS | - |
dc.subject.keywordPlus | HEPATITIS-B | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | RARE OCCURRENCE | - |
dc.subject.keywordPlus | DISEASE MELD | - |
dc.subject.keywordPlus | SERUM SODIUM | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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