Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Femtosecond laser induced nano-textured micropatterning to regulate cell functions on implanted biomaterials

Full metadata record
DC Field Value Language
dc.contributor.authorSeo, Youngmin-
dc.contributor.authorKim, Saeromi-
dc.contributor.authorLee, Hyun Soo-
dc.contributor.authorPark, Jaeho-
dc.contributor.authorLee, Kyungwoo-
dc.contributor.authorJun, Indong-
dc.contributor.authorSeo, Hyunseon-
dc.contributor.authorKim, Young Jin-
dc.contributor.authorYoo, Youngsik-
dc.contributor.authorChoi, Byoung Chan-
dc.contributor.authorSeok, Hyun-Kwang-
dc.contributor.authorKim, Yu-Chan-
dc.contributor.authorOk, Myoung-Ryul-
dc.contributor.authorChoi, Jonghoon-
dc.contributor.authorJoo, Choun-Ki-
dc.contributor.authorJeon, Hojeong-
dc.date.available2020-10-30T09:40:37Z-
dc.date.issued2020-10-
dc.identifier.issn1742-7061-
dc.identifier.issn1878-7568-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43430-
dc.description.abstractPosterior capsular opacification (PCO) is the most common complication of cataract surgery. PCO is due to the proliferation, migration, and epithelial-to-mesenchymal transition of the residual lens epithelial cells (LECs) within the lens capsule. As surface topography influences cellular response, we investigated the effect of modulating the dimensions of periodic nano-textured patterns on the surface of an intraocular lens material to regulate lens epithelial cell functions such as cell adhesion, migration, orientation, and proliferation. Patterned poly(HEMA) samples were prepared by a femtosecond laser microfabrication, and the behaviors of human B-3 LECs were observed on groove/ridge patterns with widths varying from 5 to 40 µm. In the presence of ridge and groove patterns, the adherent cells elongated along the direction of the patterns, and f-actin of the cells was spread to a lesser extent on the nano-textured groove surfaces. Both single and collective cell migrations were significantly inhibited in the perpendicular direction of the patterns on the nano-textured micro-patterned samples. We also fabricated the patterns on the curved surface of a commercially available intraocular lens for in vivo evaluation. In vivo results showed that a patterned IOL could help suppress the progression of PCO by inhibiting cell migration from the edge to the center of the IOL. Our reports demonstrate that nano- and microscale topographical patterns on a biomaterial surface can regulate cellular behavior when it is implanted into animals. © 2020-
dc.format.extent11-
dc.language영어-
dc.language.isoENG-
dc.publisherActa Materialia Inc-
dc.titleFemtosecond laser induced nano-textured micropatterning to regulate cell functions on implanted biomaterials-
dc.typeArticle-
dc.identifier.doi10.1016/j.actbio.2020.08.044-
dc.identifier.bibliographicCitationActa Biomaterialia, v.116, pp 138 - 148-
dc.description.isOpenAccessN-
dc.identifier.wosid000577516000007-
dc.identifier.scopusid2-s2.0-85090480202-
dc.citation.endPage148-
dc.citation.startPage138-
dc.citation.titleActa Biomaterialia-
dc.citation.volume116-
dc.type.docTypeArticle-
dc.publisher.location영국-
dc.subject.keywordAuthorCell migration-
dc.subject.keywordAuthorFemtosecond laser-
dc.subject.keywordAuthorMicropattern-
dc.subject.keywordAuthorNano-texturing-
dc.subject.keywordAuthorPosterior capsular opacification-
dc.subject.keywordPlusPOSTERIOR CAPSULAR OPACIFICATION-
dc.subject.keywordPlusACRYLIC INTRAOCULAR-LENS-
dc.subject.keywordPlusBAG OPACIFICATION-
dc.subject.keywordPlusCATARACT-SURGERY-
dc.subject.keywordPlusPREVENTION-
dc.subject.keywordPlusMIGRATION-
dc.subject.keywordPlusORGANIZATION-
dc.subject.keywordPlusTOPOGRAPHY-
dc.subject.keywordPlusNANOSCALE-
dc.subject.keywordPlusBLINDNESS-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, Jonghoon photo

Choi, Jonghoon
창의ICT공과대학 (융합공학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE