Femtosecond laser induced nano-textured micropatterning to regulate cell functions on implanted biomaterials
DC Field | Value | Language |
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dc.contributor.author | Seo, Youngmin | - |
dc.contributor.author | Kim, Saeromi | - |
dc.contributor.author | Lee, Hyun Soo | - |
dc.contributor.author | Park, Jaeho | - |
dc.contributor.author | Lee, Kyungwoo | - |
dc.contributor.author | Jun, Indong | - |
dc.contributor.author | Seo, Hyunseon | - |
dc.contributor.author | Kim, Young Jin | - |
dc.contributor.author | Yoo, Youngsik | - |
dc.contributor.author | Choi, Byoung Chan | - |
dc.contributor.author | Seok, Hyun-Kwang | - |
dc.contributor.author | Kim, Yu-Chan | - |
dc.contributor.author | Ok, Myoung-Ryul | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.contributor.author | Joo, Choun-Ki | - |
dc.contributor.author | Jeon, Hojeong | - |
dc.date.available | 2020-10-30T09:40:37Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.issn | 1878-7568 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43430 | - |
dc.description.abstract | Posterior capsular opacification (PCO) is the most common complication of cataract surgery. PCO is due to the proliferation, migration, and epithelial-to-mesenchymal transition of the residual lens epithelial cells (LECs) within the lens capsule. As surface topography influences cellular response, we investigated the effect of modulating the dimensions of periodic nano-textured patterns on the surface of an intraocular lens material to regulate lens epithelial cell functions such as cell adhesion, migration, orientation, and proliferation. Patterned poly(HEMA) samples were prepared by a femtosecond laser microfabrication, and the behaviors of human B-3 LECs were observed on groove/ridge patterns with widths varying from 5 to 40 µm. In the presence of ridge and groove patterns, the adherent cells elongated along the direction of the patterns, and f-actin of the cells was spread to a lesser extent on the nano-textured groove surfaces. Both single and collective cell migrations were significantly inhibited in the perpendicular direction of the patterns on the nano-textured micro-patterned samples. We also fabricated the patterns on the curved surface of a commercially available intraocular lens for in vivo evaluation. In vivo results showed that a patterned IOL could help suppress the progression of PCO by inhibiting cell migration from the edge to the center of the IOL. Our reports demonstrate that nano- and microscale topographical patterns on a biomaterial surface can regulate cellular behavior when it is implanted into animals. © 2020 | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Acta Materialia Inc | - |
dc.title | Femtosecond laser induced nano-textured micropatterning to regulate cell functions on implanted biomaterials | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.actbio.2020.08.044 | - |
dc.identifier.bibliographicCitation | Acta Biomaterialia, v.116, pp 138 - 148 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000577516000007 | - |
dc.identifier.scopusid | 2-s2.0-85090480202 | - |
dc.citation.endPage | 148 | - |
dc.citation.startPage | 138 | - |
dc.citation.title | Acta Biomaterialia | - |
dc.citation.volume | 116 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Cell migration | - |
dc.subject.keywordAuthor | Femtosecond laser | - |
dc.subject.keywordAuthor | Micropattern | - |
dc.subject.keywordAuthor | Nano-texturing | - |
dc.subject.keywordAuthor | Posterior capsular opacification | - |
dc.subject.keywordPlus | POSTERIOR CAPSULAR OPACIFICATION | - |
dc.subject.keywordPlus | ACRYLIC INTRAOCULAR-LENS | - |
dc.subject.keywordPlus | BAG OPACIFICATION | - |
dc.subject.keywordPlus | CATARACT-SURGERY | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | TOPOGRAPHY | - |
dc.subject.keywordPlus | NANOSCALE | - |
dc.subject.keywordPlus | BLINDNESS | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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