Hydrogen Bonding and Molecular Recognition: Synthetic, Complexation, and Structural Studies on Barbiturate Binding to an Artificial Receptor
DC Field | Value | Language |
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dc.contributor.author | Chang, Suk-Kyu | - |
dc.contributor.author | Van Engen, Donna | - |
dc.contributor.author | Fan, Erkang | - |
dc.contributor.author | Hamilton, Andrew D. | - |
dc.date.available | 2021-01-25T06:41:53Z | - |
dc.date.issued | 1991-09 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.issn | 1520-5126 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43674 | - |
dc.description.abstract | A series of synthetic receptors with strong selectivity for the barbiturate family of drugs has been prepared. The receptor design is based on two 2,6-diaminopyridine groups linked through an isophthalic acid spacer. X-ray crystallographic, H-1 NMR spectroscopic, and substrate binding studies confirm that six hydrogen bonds are formed between the receptor and its substrate. The strongest binding (K(a) almost-equal-to 10(5) M-1) is seen to those substrates containing the complementary barbituric acid core. Systematic deletion of hydrogen-bonding sites from the receptor and substrate allows an assessment of the contribution of individual binding sites to complexation. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Hydrogen Bonding and Molecular Recognition: Synthetic, Complexation, and Structural Studies on Barbiturate Binding to an Artificial Receptor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ja00020a027 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.113, no.20, pp 7640 - 7645 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | A1991GH05800027 | - |
dc.identifier.scopusid | 2-s2.0-0025989335 | - |
dc.citation.endPage | 7645 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 7640 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 113 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | NUCLEOTIDE BASE RECOGNITION | - |
dc.subject.keywordPlus | STACKING INTERACTIONS | - |
dc.subject.keywordPlus | MACROCYCLIC RECEPTOR | - |
dc.subject.keywordPlus | ORGANIC-SOLVENT | - |
dc.subject.keywordPlus | FREE-ENERGY | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | ADENINE | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | STABILITY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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