An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2
DC Field | Value | Language |
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dc.contributor.author | Shin, Eunkyoung | - |
dc.contributor.author | Jin, Hanyong | - |
dc.contributor.author | Suh, Dae-Shik | - |
dc.contributor.author | Luo, Yongyang | - |
dc.contributor.author | Ha, Hye-Jeong | - |
dc.contributor.author | Kim, Tae Heon | - |
dc.contributor.author | Hahn, Yoonsoo | - |
dc.contributor.author | Hyun, Seogang | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Bae, Jeehyeon | - |
dc.date.available | 2021-03-06T04:40:12Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.issn | 1460-2075 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43769 | - |
dc.description.abstract | Recent evidence suggests that animal microRNAs (miRNAs) can target coding sequences (CDSs); however, the pathophysiological importance of such targeting remains unknown. Here, we show that a somatic heterozygous missense mutation (c.402C>G; p.C134W) in FOXL2, a feature shared by virtually all adult-type granulosa cell tumors (AGCTs), introduces a target site for miR-1236, which causes haploinsufficiency of the tumor-suppressor FOXL2. This miR-1236-mediated selective degradation of the variant FOXL2 mRNA is preferentially conducted by a distinct miRNA-loaded RNA-induced silencing complex (miRISC) directed by the Argonaute3 (AGO3) and DHX9 proteins. In both patients and a mouse model of AGCT, abundance of the inversely regulated variant FOXL2 with miR-1236 levels is highly correlated with malignant features of AGCT. Our study provides a molecular basis for understanding the conserved FOXL2 CDS mutation-mediated etiology of AGCT, revealing the existence of a previously unidentified mechanism of miRNA-targeting disease-associated mutations in the CDS by forming a non-canonical miRISC. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2 | - |
dc.type | Article | - |
dc.identifier.doi | 10.15252/embj.2020104719 | - |
dc.identifier.bibliographicCitation | The EMBO Journal, v.39, no.24 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000590563100001 | - |
dc.identifier.scopusid | 2-s2.0-85096774329 | - |
dc.citation.number | 24 | - |
dc.citation.title | The EMBO Journal | - |
dc.citation.volume | 39 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | allelic imbalance | - |
dc.subject.keywordAuthor | Argonaute3 | - |
dc.subject.keywordAuthor | DHX9 | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | miR-1236 | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR FOXL2 | - |
dc.subject.keywordPlus | GRANULOSA-CELL TUMORS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | MICRORNA TARGETS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | REGIONS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | POLYADENYLATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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