Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive T-1 Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchyrnal Stem Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Taeho | - |
dc.contributor.author | Momin, Eric | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.contributor.author | Yuan, Kristy | - |
dc.contributor.author | Zaidi, Hasan | - |
dc.contributor.author | Kim, Jaeyun | - |
dc.contributor.author | Park, Mihyun | - |
dc.contributor.author | Lee, Nohyun | - |
dc.contributor.author | McMahon, Michael T. | - |
dc.contributor.author | Quinones-Hinojosa, Alfredo | - |
dc.contributor.author | Bulte, Jeff W. M. | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Gilad, Assaf A. | - |
dc.date.available | 2021-04-23T10:30:09Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.issn | 1520-5126 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43900 | - |
dc.description.abstract | Mesoporous silica-coated hollow manganese oxide (HIVInO@ mSiO(2)) nanoparticles were developed as a novel T-1 magnetic resonance imaging (MRI) contrast agent. We hypothesized that the mesoporous structure of the nanopartide shell enables optimal access of water molecules to the magnetic core, and consequently, an effective longitudinal (R-1) relaxation enhancement of water protons, which value was measured to be 0.99 (mM(-1) s(-1)) at 11.7 T. Adipose-derived mesenchymal stem cells (MSCs) were efficiently labeled using electroporation, with much shorter T-1 values as compared to direct incubation without electroporation, which was also evidenced by signal enhancement on T-1-weighted MR images in vitro. Intracranial grafting of HMnO@mSiO(2)-labeled MSCs enabled serial MR monitoring of cell transplants over 14 days. These novel nanopartides may extend the arsenal of currently available nanoparticie MR contrast agents by providing positive contrast on T-1-weighted images at high magnetic field strengths. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive T-1 Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchyrnal Stem Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ja1084095 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, no.9, pp 2955 - 2961 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000289455200032 | - |
dc.identifier.scopusid | 2-s2.0-79952260309 | - |
dc.citation.endPage | 2961 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2955 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 133 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE TRACKING | - |
dc.subject.keywordPlus | IN-VIVO TRACKING | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | SHELL | - |
dc.subject.keywordPlus | SEMICONDUCTOR | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | CORE | - |
dc.subject.keywordPlus | DRUG | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.