Lithium attenuates d-amphetamine-induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase-2 and indoleamine-2,3-dioxygenase
DC Field | Value | Language |
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dc.contributor.author | Phan, Dieu-Hien | - |
dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Tran, Hai-Quyen | - |
dc.contributor.author | Sharma, Naveen | - |
dc.contributor.author | Nguyen, Bao Trong | - |
dc.contributor.author | Jung, Tae Woo | - |
dc.contributor.author | Nah, Seung-Yeol | - |
dc.contributor.author | Saito, Kuniaki | - |
dc.contributor.author | Nabeshima, Toshitaka | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.date.accessioned | 2021-06-18T07:15:26Z | - |
dc.date.available | 2021-06-18T07:15:26Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0305-1870 | - |
dc.identifier.issn | 1440-1681 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/44204 | - |
dc.description.abstract | In the present study, we investigated whether mood stabilizer lithium (Li) protects against d-amphetamine (AMP)-induced mania-like behaviours via modulating the novel proinflammatory potential. Repeated treatment with AMP resulted in significant increases in proinflammatory cyclooxygenase-2 (COX-2) and indolemaine-2,3-dioxygenase-1 (IDO)-1 expression in the prefrontal cortex (PFC) of mice. However, AMP treatment did not significantly change IDO-2 and 5-lipoxygenase (5-LOX) expression, suggesting that proinflammatory parameters such as COX-2 and IDO-1 are specific for AMP-induced behaviours. AMP-induced initial expression of COX-2 (15 minutes post-AMP) was earlier than that of IDO-1 (1 hour post-AMP). Mood stabilizer Li and COX-2 inhibitor meloxicam significantly attenuated COX-2 expression 15 minutes post-AMP, whereas IDO-1 inhibitor 1-methyl-DL-tryptophan (1-MT) did not affect COX-2 expression. However, AMP-induced IDO-1 expression was significantly attenuated by Li, meloxicam or 1-MT, suggesting that COX-2 is an upstream molecule for the induction of IDO-1 caused by AMP. Consistently, co-immunoprecipitation between COX-2 and IDO-1 was observed at 30 minutes, 1, 3, and 6 hours after the final AMP treatment. This interaction was also significantly inhibited by Li, meloxicam or 1-MT. Furthermore, AMP-induced hyperlocomotion was significantly attenuated by Li, meloxicam or 1-MT. We report, for the first time, that mood stabilizer Li attenuates AMP-induced mania-like behaviour via attenuation of interaction between COX-2 and IDO-1, and that the interaction of COX-2 and IDO-1 may be critical for the therapeutic intervention mediated by mood stabilizer. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Lithium attenuates d-amphetamine-induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase-2 and indoleamine-2,3-dioxygenase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/1440-1681.13243 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, v.47, no.5, pp 790 - 797 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000508960400001 | - |
dc.identifier.scopusid | 2-s2.0-85078675393 | - |
dc.citation.endPage | 797 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 790 | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | - |
dc.citation.volume | 47 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | D-amphetamine-induced mania-like behaviour | - |
dc.subject.keywordAuthor | interaction of COX-2 and IDO-1 | - |
dc.subject.keywordAuthor | lithium | - |
dc.subject.keywordAuthor | prefrontal cortex | - |
dc.subject.keywordPlus | CYTOSOLIC PHOSPHOLIPASE A(2) | - |
dc.subject.keywordPlus | ARACHIDONIC-ACID CASCADE | - |
dc.subject.keywordPlus | INDUCED DOPAMINE RELEASE | - |
dc.subject.keywordPlus | BIPOLAR DISORDER | - |
dc.subject.keywordPlus | LOCOMOTOR RESPONSE | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | MOOD STABILIZERS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | ANIMAL-MODEL | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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