Del-1, an Endogenous Inhibitor of TGF-β Activation, Attenuates Fibrosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Dong-Young | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.contributor.author | Fu, Yan | - |
dc.contributor.author | Jing, Feifeng | - |
dc.contributor.author | Kim, Won-Young | - |
dc.contributor.author | Hong, Sang-Bum | - |
dc.contributor.author | Song, Jung-A | - |
dc.contributor.author | Choe, Han | - |
dc.contributor.author | Ryu, Hyun Jin | - |
dc.contributor.author | Kim, Minjung | - |
dc.contributor.author | Lim, Dahae | - |
dc.contributor.author | Kim, Min-Seon | - |
dc.contributor.author | Yun, Chae-Ok | - |
dc.contributor.author | Lee, Taewon | - |
dc.contributor.author | Hyun, Hoon | - |
dc.contributor.author | Choi, Eun Young | - |
dc.date.accessioned | 2021-06-18T07:17:19Z | - |
dc.date.available | 2021-06-18T07:17:19Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/44302 | - |
dc.description.abstract | Uncontrolled activation of transforming growth factor (TGF)-β results in a wide range of pathologic conditions. Therapeutic interventions to regulate TGF-β signaling during fibrosis have been developed but the effectiveness is still limited. Here, we show that developmental endothelial locus-1 (Del-1) ameliorates fibrosis in mice by inhibiting αv integrin-mediated activation of TGF-β. Del-1 bound to αvβ6 integrin, an important activator of TGF-β, and inhibited the binding of αvβ6 integrin to the latency-associated peptide (LAP), thereby suppressing αv integrin-mediated activation of TGF-β. Lack of Del-1 increased colocalization of αv integrin and LAP in the lungs, which was reversed by Del-1 supplementation. The crucial role of Del-1 in regulating TGF-β activity was recapitulated in a mouse model of fibrosis using an adenovirus expressing inactive TGF-β1. Del-1 supplementation improved the pathological characteristics of the mice and reduced mortality. Thus, we propose that Del-1 is a negative regulator of TGF-β activation and a potential anti-fibrotic factor. © Copyright © 2020 Kim, Lee, Fu, Jing, Kim, Hong, Song, Choe, Ryu, Kim, Lim, Kim, Yun, Lee, Hyun and Choi. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Del-1, an Endogenous Inhibitor of TGF-β Activation, Attenuates Fibrosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fimmu.2020.00068 | - |
dc.identifier.bibliographicCitation | Frontiers in Immunology, v.11 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000517277600001 | - |
dc.identifier.scopusid | 2-s2.0-85079648522 | - |
dc.citation.title | Frontiers in Immunology | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Del-1 (developmental endothelial locus-1) | - |
dc.subject.keywordAuthor | fibrosis | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | integrins | - |
dc.subject.keywordAuthor | transforming growth factor-beta activation | - |
dc.subject.keywordPlus | DEVELOPMENTAL ENDOTHELIAL LOCUS-1 | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | INDUCED PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EFFEROCYTOSIS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INTEGRINS | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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