Acute effects of continuous positive airway pressure in patients with obstructive sleep apnea
- Authors
- Han, Su-Hyun; Lee, Sang-Ahm
- Issue Date
- Jan-2020
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Obstructive sleep apnea; sleep disordered breathing; continuous positive airway pressure; hypertension; blood pressure
- Citation
- SCANDINAVIAN CARDIOVASCULAR JOURNAL, v.54, no.1, pp 26 - 31
- Pages
- 6
- Journal Title
- SCANDINAVIAN CARDIOVASCULAR JOURNAL
- Volume
- 54
- Number
- 1
- Start Page
- 26
- End Page
- 31
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/44338
- DOI
- 10.1080/14017431.2019.1659395
- ISSN
- 1401-7431
1651-2006
- Abstract
- Objectives. To enhance the initial compliance of continuous positive airway pressure (CPAP) in the patient with obstructive sleep apnea (OSA), we investigate the acute effects of one-night CPAP on morning blood pressure (BP) and, if any exist, to determine which factors predict BP-lowering effects of one-night CPAP in OSA subgroups stratified by the presence or absence of uncontrolled hypertension. Design. Newly diagnosed OSA patients (a respiratory distress index (RDI) >= 15) without a history of hypertension were stratified by the presence or absence of morning hypertension. Comparisons were made of morning BP, overnight change in mean BP (MBP), and circadian BP pattern (R-M/E, the ratio of morning to evening MBP) between two time points of diagnostic and CPAP titrations in each subgroup. In the subgroup with a significantly reduced morning BP, predictors of changes in morning MBP were determined by multiple linear regression analyses. Results. The prevalence of morning hypertension was 48.8%. One-night CPAP reduced BP immediately only in patients with morning hypertension. By contrast, patients without morning hypertension did not experience any BP-lowering effects. In the subgroup with morning hypertension, baseline morning MBP, female sex, and R-M/E were independently associated with reduced morning MBP, and R-M/E was the most important predictor. Conclusions. These results confirm the acute effects of one-night CPAP on lowering BP in OSA patients with morning hypertension. An unfavorable circadian BP pattern is the most important predictor.
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