Circulating Tumor Cell Counts in Patients With Localized Prostate Cancer Including Those Under Active Surveillance
DC Field | Value | Language |
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dc.contributor.author | Choi, Se Young | - |
dc.contributor.author | Lim, Bumjin | - |
dc.contributor.author | Kyung, Yoon Soo | - |
dc.contributor.author | Kim, Yunlim | - |
dc.contributor.author | Kim, Bong Min | - |
dc.contributor.author | Jeon, Byung Hee | - |
dc.contributor.author | Park, Jae Chan | - |
dc.contributor.author | Sohn, Young Woong | - |
dc.contributor.author | Lee, Jae Hyuk | - |
dc.contributor.author | Uh, Ji-Hyun | - |
dc.contributor.author | Jang, Seongsoo | - |
dc.contributor.author | Kim, Choung-Soo | - |
dc.date.accessioned | 2021-06-18T07:24:02Z | - |
dc.date.available | 2021-06-18T07:24:02Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0258-851X | - |
dc.identifier.issn | 1791-7549 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/44704 | - |
dc.description.abstract | Aim: To evaluate the clinical efficacy of a circulating tumor cell (CTC) test by comparison between healthy volunteers and patients with localized prostate cancer including those under active surveillance. Materials and Methods: CTC counts in peripheral blood were compared between patients with prostate cancer (n=45) and healthy volunteers (n=17). CTCs were identified based on the expression of epithelial cell adhesion molecule (EpCAM) and counted using a SMART BIOPSY (TM) SYSTEM. Results: The number of EpCAM+ cells was significantly higher in patients with cancer than in healthy volunteers. Among the low-risk patients (n=9), two had up-staging and six had up-grading. Among those up-staged, there was one case which was EpCAM(+). Among those cases up-graded, three were EpCAM(+). In those with stage T2 tumors, the presence of Gleason pattern 5 was positively correlated with EpCAM positivity (rho=0.59, p<0.001). Conclusion: CTC counts in localized prostate cancer were associated with Gleason pattern 5. Active treatment should be considered for patients with low-risk disease during active surveillance who are found to have EpCAM+ CTCs because of a risk of up-staging and upgrading. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.title | Circulating Tumor Cell Counts in Patients With Localized Prostate Cancer Including Those Under Active Surveillance | - |
dc.type | Article | - |
dc.identifier.doi | 10.21873/invivo.11645 | - |
dc.identifier.bibliographicCitation | IN VIVO, v.33, no.5, pp 1615 - 1620 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000484008000030 | - |
dc.identifier.scopusid | 2-s2.0-85071753053 | - |
dc.citation.endPage | 1620 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1615 | - |
dc.citation.title | IN VIVO | - |
dc.citation.volume | 33 | - |
dc.type.docType | Article | - |
dc.publisher.location | 그리이스 | - |
dc.subject.keywordAuthor | Prostate biopsy | - |
dc.subject.keywordAuthor | biomarker | - |
dc.subject.keywordAuthor | EpCAM | - |
dc.subject.keywordAuthor | PSMA | - |
dc.subject.keywordAuthor | prostatectomy | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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