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Validation of the Uniform Case Definition Criteria for Differentiating Tuberculous Meningitis, Viral Meningitis, and Bacterial Meningitis in Adultsopen access
- Authors
- Kim, Min-Chul; Park, Ki-Ho; Lee, Sang-Ahm; Kim, Sung-Han
- Issue Date
- Jun-2019
- Publisher
- KOREAN SOC CHEMOTHERAPY
- Keywords
- Tuberculous meningitis; The uniform tuberculous meningitis case definition; Differentiation; Viral meningitis; Bacterial meningitis
- Citation
- INFECTION AND CHEMOTHERAPY, v.51, no.2, pp 188 - 190
- Pages
- 3
- Journal Title
- INFECTION AND CHEMOTHERAPY
- Volume
- 51
- Number
- 2
- Start Page
- 188
- End Page
- 190
- ISSN
- 2093-2340
2092-6448
- Abstract
- We validated the uniform case definition for differentiating tuberculous meningitis (TBM) from both viral meningitis (VM) and bacterial meningitis (BM) in adults from South Korea, a country with an intermediate TB-burden. 'Probable' TBM differentiated 'definite' TBM with a sensitivity of 81% and specificity of 98%. 'Possible TBM' criteria identified 'definite' TBM with a sensitivity of 100% and specificity of 60%. Despite the usefulness of the uniform case definition criteria, there was substantial overlaps among VM, BM, and 'possible' TBM, especially in severe cases of VM and indolent cases of BM.
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